Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease

Cheng, Jing; Kalliomäki, Marko; Heilig, Hans G.H.J.; Palva, Airi; Lähteenoja, Hannu; Vos, Willem M. de; Salojärvi, Jarkko; Satokari, Reetta

doi:10.1186/1471-230x-13-113

Cited by 131 publications

(147 citation statements)

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“…Numerous studies have identified associations between aberrant composition of microbiota in children and diseases including atopic diseases, autism, obesity, Crohn´s disease, celiac disease and food allergies (Kalliomäki et al, 2008;Cucchiara et al, 2009;Frank et al, 2011;Cheng et al, 2013;Azad et al, 2014;Nylund et al, 2015;Toh and AllenVercoe, 2015). Decreased diversity and richness of microbiota has been linked to several disorders (Turnbaugh and Gordon, 2009;Verdam et al, 2013;Nylund et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

et al. 2015

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The colonization pattern of intestinal microbiota during childhood may impact health later in life, but children older than 1 year are poorly studied. We followed healthy children aged 1-4 years (n = 28) for up to 12 months, during which a synbiotic intervention and occasional antibiotics intake occurred, and compared them with adults from the same region. Microbiota was quantified with the HITChip phylogenetic microarray and analyzed with linear mixed effects model and other statistical approaches. Synbiotic administration increased the stability of Actinobacteria and antibiotics decreased Clostridium cluster XIVa abundance. Bacterial diversity did not increase in 1-to 5-year-old children and remained significantly lower than in adults. Actinobacteria, Bacilli and Clostridium cluster IV retained child-like abundances, whereas some other groups were converting to adult-like profiles. Microbiota stability increased, with Bacteroidetes being the main contributor. The common core of microbiota in children increased with age from 18 to 25 highly abundant genus-level taxa, including several butyrate-producing organisms, and developed toward an adult-like composition. In conclusion, intestinal microbiota is not established before 5 years of age and diversity, core microbiota and different taxa are still developing toward adult-type configuration. Discordant development patterns of bacterial phyla may reflect physiological development steps in children.

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Section: Introductionmentioning

confidence: 99%

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

et al. 2015

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“…Recently, study of the human gut microbiome has been applied to CD pathogenesis (Sellito et al 2012;Cheng et al 2013;Sjöberg et al 2013). Almost a decade ago, Forsberg and colleagues (2004) In contrast, a slightly later study by Cheng and colleagues (2013) found no significant differences in the overall composition and diversity of gut microbiota (including Bacteroidetes) between a sample of 10 children with newly diagnosed CD (aged 3-14) and 9 healthy controls (aged 4-16).…”

Section: Presentation Pathophysiology and Genetics Of CDmentioning

confidence: 99%

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Sams

Hawks

2014

Human Biology

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Abstract. Celiac disease (CD) is a multifactorial chronic inflammatory conditionthat results in injury of the mucosal lining of the small intestine upon ingestion of wheat gluten and related proteins from barley and rye. Although the exact mechanisms leading to CD are not fully understood, the genetic basis of CD has been relatively well characterized. In this review we briefly review the history of discovery, clinical presentation, pathophysiology, and current understanding of the genetics underlying CD risk. Then, we discuss what is known about the current distribution and evolutionary history of genes underlying CD risk in light of other evolutionary models of disease. Specifically, we conclude that the set of loci underlying CD risk did not cohesively evolve as a response to a single past selection event such as the development of agriculture. Rather, deterministic and stochastic evolutionary processes have both contributed to the present distribution of variation in CD risk loci. Selection has shaped some components of this network, but this selection appears to have occurred at different points in the past.Other parts of the CD risk network have likely arisen due to stochastic processes such as genetic drift. Celiac disease (CD) is a multifactorial chronic inflammatory condition that resultsin injury of the mucosal lining of the small intestine. The earliest descriptions of a condition with symptoms like CD date back to the first and second century writings of the Greek physician Arataeus (Simoons 1981;Losowsky 2008). The first modern description of CD is attributed to English physician Samuel Jones Gee, who was familiar with the writings of Arataeus. In 1888 (Dowd and Walker-Smith 1974;Simoons 1981;Losowsky 2008) Gee described the 'coeliac affection' as a condition of chronic indigestion associated with diarrhea, wasting, and weakness and common in people of all ages. Gee's report was the first to hypothesize dietary factors as a primary cause of the condition (Dowd and Walker-Smith 1974), and during the early twentieth century some workers noted the value of a starch free diet for prevention of CD (Haas 1924). Dicke and colleagues (1950, 1953) observed the detrimental effect of wheat flour (but not wheat starch) on CD patients experimentally confirming a role for diet as a driver of CD. Shortly thereafter, Anderson and colleagues (Anderson et al. 1952;Alvey et al. 1957) confirmed the effect of wheat on CD and identified wheat gluten as the primary culprit.CD appears to be an evolutionary paradox. Only since the 1950s have clinicians recognized that a gluten-free diet is an effective treatment (Barker and Liu 2008). Before that time, diagnosed and undiagnosed CD reduced the health and fitness of sufferers, with juvenile cases leading to malnutrition or death, and adult cases causing wasting, lack of adequate nutrition, greater susceptibility to infection, and direct reductions in fertility (Corrao et al. 2001;Soni and Badawy 2010). Despite these apparent costs, CD is common today (>1%) in several popul...

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“…Indeed, deviations in faecal and duodenal microbiota associated with CD have been reported (149,(151)(152)(153) , although recent studies utilising high-throughput methods have reported comparable microbiota compositions in patients and healthy controls (154)(155)(156)(157) . A recent study utilising a highthroughput microarray method in analysing duodenal biopsies of paediatric CD patients in Finland found that while the overall microbiota composition was comparable between CD and healthy subjects, a profile of eight bacterial groups was observed to distinguish patients from healthy controls (157) . This profile was characterised by higher abundances of bacteria related to Prevotella melaninogenica, Haemophilus and Serratia spp., whereas those related to P. oralis, P. cinnamivorans, Ruminococcus bromiii, Proteus and Clostridium stercorarium were decreased in CD patients (157) .…”

Section: Coeliac Diseasementioning

confidence: 99%

“…In contrast to declined proportions of Gram-positives, Gram-negative bacteria such as Clostridium groups (160,163) , Prevotella spp. (157,159) and E. coli (153,163) seem to be increased in paediatric CD patients. The most constant finding is the higher abundance of Bacteroides spp.…”

Section: Coeliac Diseasementioning

confidence: 99%

“…A recent study utilising a highthroughput microarray method in analysing duodenal biopsies of paediatric CD patients in Finland found that while the overall microbiota composition was comparable between CD and healthy subjects, a profile of eight bacterial groups was observed to distinguish patients from healthy controls (157) . This profile was characterised by higher abundances of bacteria related to Prevotella melaninogenica, Haemophilus and Serratia spp., whereas those related to P. oralis, P. cinnamivorans, Ruminococcus bromiii, Proteus and Clostridium stercorarium were decreased in CD patients (157) . Also the total abundance of Prevotella spp.…”

Section: Coeliac Diseasementioning

confidence: 99%

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Intestinal microbiota during early life – impact on health and disease

et al. 2014

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In the first years after birth, the intestinal microbiota develops rapidly both in diversity and complexity while being relatively stable in healthy adults. Different life-style-related factors as well as medical practices have an influence on the early-life intestinal colonisation. We address the impact of some of these factors on the consecutive microbiota development and later health. An overview is presented of the microbial colonisation steps and the role of the host in that process. Moreover, new early biomarkers are discussed with examples that include the association of microbiota and atopic diseases, the correlation of colic and early development and the impact of the use of antibiotics in early life. Our understanding of the development and function of the intestinal microbiota is constantly improving but the long-term influence of early-life microbiota on later life health deserves careful clinical studies.Microbiota development: Human milk oligosaccharides: Weaning: Biomarker bacteria:Allergy and atopic diseases: Colic: Antibiotics

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Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease

Cited by 131 publications

References 65 publications

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Intestinal microbiota during early life – impact on health and disease

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