Duration for carrying SARS-CoV-2 in COVID-19 patients

Abstract

Duration for carrying SARS-CoV-2 in COVID-19 patientsDear editor , We read with interest the report that written by Yu and colleagues. 1 This report retrospectively analyzed laboratory-confirmed novel coronavirus disease 2019 (COVID-19) pneumonia patients and summarized the clinical characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reactivation. However, deep understanding of SARS-CoV-2 carrying duration, the time of infection, as well as its antiviral treatment period can contribute to the management and treatment for COVID-19.The COVID-19 caused by SARS-CoV-2 has transmitted quickly as a global public health emergency, with the characteristics of a high contagiosity, quick transmission and general susceptibility. 2 Previous studies mainly focused on the epidemiological, clinical characteristics, as well as prevention and control measures of COVID-19. 3 However, few studies demonstrated the duration for SARS-CoV-2 carrying in COVID-19 patients. Here, we collected the positive SARS-CoV-2 nucleic acid cases and examined the duration for SARS-CoV-2 carrying and its characteristics in different populations.From January 20, 2020 to March 1, 2020, inpatients with a specific SARS-CoV-2 epidemiological history and a positive SARS-CoV-2 nucleic acid test were collected in this retrospective study in Henan province. We compared the durations for carrying virus SARS-CoV-2 in different ages, gender, disease condition. The duration for SARS-CoV-2 carrying was defined as the time from a close contact with the source of infection to the last positive test for COVID-19 virus. Cases in this study were also divided into severe group and non-severe group to study. The definitions of severe group (including critically ill) and group of the non-severe type were in Table 1 .

Early Hydroxychloroquine Administration for Rapid Severe Acute Respiratory Syndrome Coronavirus 2 Eradication

“…Previous studies showed that age, male sex, time from illness onset to hospitalization, invasive mechanical ventilation, and severe disease are associated with persistent existence of SARS-CoV-2 [2,10]. Here, administration of HCQ <5 days from diagnosis (OR: 0.111, 95% CI: 0.034 -0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients.…”

“…Our data reveals that early administration of HCQ is associated with shorter viral shedding duration and a higher rate of viral clearance after 30 days, despite the initial assessment of high disease severity. https://icjournal.org https://doi.org/10.3947/ic.2020.52.3.396 In a recent study, it was demonstrated that severe COVID-19 patients tend to have high viral load and prolonged viral shedding period, which correspond to poor clinical outcomes [10,11].…”

Retrospective analysis of the effect of current clinical medications and clinicopathological factors on viral shedding in COVID‑19 patients

“…These drugs include IFN-α and ribavirin, as well as lopinavir/ritonavir (LPV/r) and Umifenovir as antiviral drugs. Several studies have described the effects of antiviral on the duration of viral shedding (6)(7)(8) and other studies have assessed the differences in the duration of viral shedding between patients with different degrees of severity of infection (9). Recently, obesity was identified as a risk factor for increased COVID-19 prevalence, severity and lethality (10), and modulation of zinc status may be beneficial in the management COVID-19 (11).…”

Az új típusú koronavírus okozta megbetegedés (COVID–19): összefoglaló hematológusoknak I. – virológia, molekuláris patogenezis és klinikum

“…A májban fokális necrosis mellett lobularis lymphoid infi ltráció látszódott, ugyanakkor a szívben jellemző morfológiai elváltozást rendszerint nem lehetett felfedezni [42,[49][50][51]. [10,[52][53][54][55][56][57][58].…”

“…rossz eszközzel, nem megfelelő anatómiai lokalizációból és módon gyűjtött minta stb. ), így a PCR-eredmény -az egyébként még RNS-ürítő embernél -tévesen negatív lesz [10,[52][53][54][55][56][57][58].…”