DXA body composition corrective factors between Hologic Discovery models to conduct multicenter studies

Sutter, Thibault; Duboeuf, F.; Chapurlat, Roland; Cortet, Bernard; Lespessailles, Éric; Roux, Jean-Paul

doi:10.1016/j.bone.2020.115683

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…DXA has also been previously validated [ 23 , 24 ]. In addition, intra-center coefficients of variation were reported to be within the range of the manufacturer acceptable values (BMD: 1.40%, fat mass: 0.89%, lean mass: 0.76%) [ 25 ]. Relative SMM index of the extremities or trunk was derived from the appendicular SMM or trunk in kilograms, and the index was divided by the square of the height in meters, in line with previous studies [ 21 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Impact of appendicular and trunk skeletal muscle mass and back extensor strength on sagittal spinal alignment in Japanese women without vertebral fracture

Kudo

Miyakoshi

Hongo

et al. 2021

Osteoporosis and Sarcopenia

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Objectives Progressive and generalized loss of skeletal muscle mass (SMM) and strength are characteristics of sarcopenia. However, the impact of appendicular and trunk SMM and back extensor strength (BES) on spinal sagittal alignment remains unclear. Herein, we investigate the relationship between these factors and spinal sagittal alignment. Methods In total, 202 women without vertebral fractures (median age, 66.9 years; interquartile range, 61.4–71.9 years) were analyzed at an orthopedic outpatient clinic. Pelvic incidence (PI), lumbar lordosis (LL), sagittal vertical axis (SVA), and pelvic tilt (PT) were measured on whole spine radiographs. Body mass index (BMI), appendicular and trunk relative SMM index, and BES were also evaluated. These measurements were compared between spinal sagittal alignment groups using the Mann–Whitney U test. Finally, the factors contributing to abnormal alignment were analyzed using multiple logistic regression analysis. Results BES was significantly lower in all abnormal sagittal alignment groups, as defined by PI-LL (≥ 10°), SVA (≥4 cm), and PT (≥20°) (all P < 0.001). On multivariate analysis, BES was a contributing factor for abnormal PI-LL (P < 0.001), SVA (P = 0.001), and PT (P < 0.001). Conversely, a decrease in appendicular and trunk relative SMM index did not statistically affect abnormal spinal sagittal alignment. Conclusions BES was associated with changes in spinal sagittal alignment; however, SMM, which is often used for diagnosing sarcopenia, did not affect spinal sagittal alignment.

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Section: Methodsmentioning

confidence: 99%

Impact of appendicular and trunk skeletal muscle mass and back extensor strength on sagittal spinal alignment in Japanese women without vertebral fracture

Kudo

Miyakoshi

Hongo

et al. 2021

Osteoporosis and Sarcopenia

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show abstract

“…Dual-energy X-ray absorptiometry (DXA) was used to evaluate global and regional body composition [ 33 , 34 ]. Subjects arrived in the morning, in fasting conditions but well hydrated, as verified by a urinary specific gravity between 1,000 and 1,025, measured with a Brixco refractometer.…”

Section: Methodsmentioning

confidence: 99%

Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults

et al. 2021

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Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrome (MS). Serum musclin was measured by enzyme-linked immunosorbent assay. Insulin resistance (IR) was evaluated by the homeostatic model assessment (HOMA-IR). Body composition was determined by dual-energy X-ray absorptiometry and muscle composition by measuring carnosine in the thigh, a surrogate of fiber types, through proton magnetic resonance spectroscopy. Cardiorespiratory capacity was assessed through direct ergospirometry. Results: The control (n=29) and MS (n=61) groups were comparable in age (51.5±6.5 years old vs. 50.7±6.1 years old), sex (72.4% vs. 70.5% women), total lean mass (58.5%±7.4% vs. 57.3%±6.8%), and peak oxygen consumption (VO2peak) (31.0±5.8 mL O2./kg.min vs. 29.2±6.3 mL O2/kg.min). Individuals with MS had higher body mass index (BMI) (30.6±4.0 kg/m 2 vs. 27.4± 3.6 kg/m 2 ), HOMA-IR (3.5 [95% confidence interval, CI, 2.9 to 4.6] vs. 1.7 [95% CI, 1.1 to 2.0]), and musclin (206.7 pg/mL [95% CI, 122.7 to 387.8] vs. 111.1 pg/mL [95% CI, 63.2 to 218.5]) values than controls (P˂0.05). Musclin showed a significant relationship with HOMA-IR (β=0.23; 95% CI, 0.12 to 0.33; P˂0.01), but not with VO2peak, in multiple linear regression models adjusted for age, sex, fat mass, lean mass, and physical activity. Musclin was significantly associated with insulin, glycemia, visceral fat, and regional muscle mass, but not with BMI, VCO2peak, maximum heart rate, maximum time of work, or carnosine. Conclusion:In humans, musclin positively correlates with insulinemia, IR, and a body composition profile with high visceral adiposity and lean mass, but low body fat percentage. Musclin is not related to BMI or cardiorespiratory capacity.

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“…Analysis from the Sarcopenia Definitions and Outcomes Consortium did not show consistent associations between DXA measures of lean soft tissue and adverse outcomes in older adults [137,138]. Furthermore, DXA is a costly technique that is also influenced by body thickness, soft tissue hydration, and differences across devices and software versions [19,139,140]. Despite these limitations, DXA is a popular and useful technique as it measures three body compartments and emits low radiation doses.…”

Section: Dual Energy X-ray Absorptiometrymentioning

confidence: 99%

Advances in muscle health and nutrition: A toolkit for healthcare professionals

et al. 2022

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DXA body composition corrective factors between Hologic Discovery models to conduct multicenter studies

Cited by 9 publications

References 20 publications

Impact of appendicular and trunk skeletal muscle mass and back extensor strength on sagittal spinal alignment in Japanese women without vertebral fracture

Impact of appendicular and trunk skeletal muscle mass and back extensor strength on sagittal spinal alignment in Japanese women without vertebral fracture

Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults

Advances in muscle health and nutrition: A toolkit for healthcare professionals

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