DY131 activates ERRγ/TFAM axis to protect against metabolic disorders and acute kidney injury
Wei Gong,
Lingling Lu,
Haoyang Ma
et al.
Abstract:Renal tubular injury is considered as the main pathological feature of acute kidney injury (AKI), and mitochondrial dysfunction in renal tubular cells is implicated in the pathogenesis of AKI. The estrogen-related receptor γ (ERRγ) is a member of orphan nuclear receptors which plays a regulatory role in mitochondrial biosynthesis, energy metabolism and many metabolic pathways. Online datasets showed a dominant expression of ERRγ in renal tubules, but the role of ERRγ in AKI is still unknown. In the present stu… Show more
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