Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding – ovulation dysfunction patients

Abstract

BACKGROUND Dydrogesterone has shown significant efficacy in treatment of irregular menstrual cycle due to abnormal uterine bleeding - ovulation dysfunction (AUB-O), but there were few relevant studies. This observational study was designed to evaluate the effectiveness of dydrogesterone for the treatment of Chinese patients with AUB-O. AIM To evaluate the effects of dydrogesterone on menstrual-cycle (MC) regularization and metabolism in the patients with AUB-O. METHODS A prospective, non-interventional, single-arm, post-marketing observational study was conducted. Chinese women aged 16 years or above with AUB-O who had been prescribed dydrogesterone were enrolled. The patients were treated with dydrogesterone 10 mg from day 16 to day 25 of each cycle, consecutively for at least 3 cycles. The main outcome was defined as the percentage of patients whose MCs returned to normal (defined as 21 d < menstrual cycle ≤ 35 d) after three cycles of dydrogesterone treatment. RESULTS One hundred and fourteen women with AUB-O were enrolled in the present study. Of 89 patients who completed treatment, 72 (80.9%) achieved a regular MC at the end of the 3 rd circle. The level of androgen, including testosterone and dehydroepiandrosterone sulfate, declined significantly ( P = 0.01 and 0.031, respectively), whereas other hormone levels remained steady. During the treatment, 44/80 (55.0%) subjects in the per-protocol set had reported biphasic basal body temperature. CONCLUSION Dydrogesterone therapy was effective in achieving MC regularization for Chinese patients with AUB-O.

The effectiveness of desogestrel for endometrial protection in women with abnormal uterine bleeding-ovulatory dysfunction: a non-inferiority randomized controlled trial

“…There is a lack of evidence from randomized controlled trials, especially about the effect of treatment for AUB-O on endometrial histopathology. Most studies showed only intermediate outcomes, such as menstrual cycle regularization 15 – 17 . Our present study showed that two cyclic-progestin regimens (DSG 150 µg/d or MPA 10 mg/d, 10 d/month) could transform endometrium to complete pseudodecidualization in > 70% of cases in the treatment cycle-1 and could normalize menstruation in > 90% of all treatment cycles.…”

A Comparison between the Effectiveness of Norethisterone and Dydrogesterone for treatment of Irregular Menstrual Cycle

“…Dydrogesterone's effectiveness for menstrual cycle regulation has been reported to be equal to other orally administered progestins like Norethisterone, on eliciting secretory phase activity. 17 But these above-mentioned studies were done on the international level and no local studies have been found to compare the effectiveness of the two hormones for menstrual cycle regulation.…”

Аномальна Маткова Кровотеча: Сучасний Аналіз Етіопатогенезу, Діагностики Та Лікування

“…Затримка або відсутність овуляції, СПКЯ, призводить до нестачі прогестерону і надмірного виробництва простагландину E 2 з фолікулів яєчників, викликаючи проліферацію ендометрія і схильність до непередбачуваних менструальних кровотеч [3]. Дефіцит прогестерону і безперешкодна секреція естрогенів призводять до стійкої проліферації ендометрія й індукції виділень, що викликає АМК-O [13].…”