Dye use during amniocentesis and birth defects

Cragan, JanetD.; Martin, M. Louise; Mj, Khoury; Fernhoff, PaulM.

doi:10.1016/0140-6736(93)90867-g

Cited by 34 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The use of dyes has been discontinued since the warning of Nicolini and Monni [1] that the use of methylene blue in second-tri mester amniocentesis is strongly correlated with the occurrence of jejunal atresia in the dye-receiving twin. This experience was con firmed in the study of Van der Pol et al [2], Although an association between indigo car mine and birth defects could not be found [7], the use of any dye has been abandoned at our center. The technique described in the current report was adopted from Jeanty et al [3], It avoids the use of dye and ensures tapping of both sacs.…”

Section: Discussionmentioning

confidence: 95%

Single-Needle Insertion: An Alternative Technique for Early Second-Trimester Genetic Twin Amniocentesis

Vugt¹,

Nieuwint

Geijn³

1995

Fetal Diagn Ther

View full text Add to dashboard Cite

Single-needle insertion as an alternative technique for genetic amniocentesis in twin gestation has been evaluated in 27 pregnancies. A 22-gauge needle was inserted into the most proximal sac and amniotic fluid was aspirated. The needle was then traversed through the dividing membrane to enter the second sac and amniotic fluid was aspirated. This technique avoids the use of dye and ensures tapping of both sacs. No fetal losses attributable to the procedure occurred during the trial. In comparison with the double-needle insertion, it is a swift and easy procedure and reduces discomfort to the patient.

show abstract

Section: Discussionmentioning

confidence: 95%

Single-Needle Insertion: An Alternative Technique for Early Second-Trimester Genetic Twin Amniocentesis

Vugt¹,

Nieuwint

Geijn³

1995

Fetal Diagn Ther

View full text Add to dashboard Cite

show abstract

“…Atresia of the small bowel may occur also after the use of indigo carmine as a dye in genetic amniocentesis in twins [3,6,15]. However, Cagnan et al [3] failed to show a statistically significant increase of atresias after the use of indigo carmine.…”

Section: Discussionmentioning

confidence: 99%

“…Increased incidence of jejunal atresia after the use of indigo carmine was not reported, although three cases of jejunal atresia after intraamniotic instillation of indigo carmine were seen [3,6,15]. We report a case of jejunal atresia after instillation of toluidine blue during diagnostic amniocentesis in twins.…”

Section: Introductionmentioning

confidence: 88%

Jejunal atresia related to the use of toluidine blue in genetic amniocentesis in twins

Dinger¹,

Autenrieth²,

Kamin³

et al. 2003

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Since 1990 avoidance of methylene blue as a dye in diagnostic amniocentesis is recommended. This is the result of the observation that a high incidence of jejuno-ileal atresia appeared in twin pregnancies following intraamniotic injection of methylene blue. We report a case of jejunal atresia in twins after injection of toluidine blue. We describe the clinical course, discuss possible teratogenic mechanisms and emphasize that no synthetic dyes should be used in second trimester amniocentesis.

show abstract

“…Les tests biologiques d'aide au diagnostic de la RPM se sont progressivement imposés face au manque de pertinence des tests basés sur l'évaluation échographique de la quantité de liquide amniotique ou sur les tests d'injection intra-amniotique de colorant (indigo carmin ou phénol-sulfonephtaleine par voie transabdominale) [16][17][18][19][20]. S'il est vrai qu'un anamnios observé au deuxième trimestre dans un contexte de suspicion de rupture est un argument pré-cieux, la pertinence de cette approche est très nettement remise en cause par deux situations cliniques fréquentes : l'oligoamnios spontané en fin de grossesse et la persistance d'une quantité de liquide quasi normale après rupture [21].…”

Section: Méthodologie Diagnostique De La Rupture Des Membranesunclassified