Abstract:of the activation energy barrier, and Dx U, the distance to the transition state. For all protecting osmolytes we measure DG U increases, demonstrating that the I27 protein is stabilized. More striking is the measurement of Dx U . Unfolding the I27 protein in water gives a Dx U ¼ 2.5 Å , a distance similar to the size of a water molecule. Water molecules have been identified as integral components of the unfolding transition state of the I27 protein, forming a solvent bridge between two b-strands. By varying o… Show more
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