Dynamic Analysis of major elements in biological tissue validating quantification of trace life elements in MeV ion beam microscopy

Whitlow, Harry J.; Kuznetsov, Andrej; Azarov, Alexander; Nagy, Gyula; Frost, Robert J.W.; Henderson, Nicholas; Greco, Richard; Deoli, Naresh; Smith, Karen M.; Sudprasert, Wanwisa; Amphalop, Sumittra; Insuan, Wimonrut; Wichianchot, Sakulchit; Ren, Min-Qin; Osipowicz, Thomas; Ryan, Chris G.; Villinger, Francois

doi:10.1016/j.nimb.2024.165411

Nuclear Instruments and Methods in Physics Research Section B:

2024

DOI: 10.1016/j.nimb.2024.165411

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Dynamic Analysis of major elements in biological tissue validating quantification of trace life elements in MeV ion beam microscopy

Harry J. Whitlow,

Andrej Kuznetsov,

Alexander Azarov

et al.

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2024

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Cited by 3 publications

References 30 publications

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Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy

Whitlow,

Nagy,

Kuznetsov

et al. 2024

Physica Status Solidi (a)

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Physiologically relevant concentrations in biological tissue, in the in vivo, state are of the order of μmol L−1 and mmol L−1. Up to the present, mapping the major elements in the matrix and its thickness has been neglected, despite their importance for quantification of lesser and trace element concentrations. Ryan and Jamieson's dynamic analysis, statistical spectral decomposition approach, is developed to quantitatively measure ex vivo tissue sections cut using a cryomicrotome. This mitigates the problem that physical analysis methods require a vacuum environment. This approach is used to quantitatively image the major matrix elements H, C, N, and O as well as trace maps of Ca, Fe, and Zn in a tissue section of porcine intestine. This sample is selected as it exhibits a complex morphology with multiple tissue compartments (such as muscle and mucosa, as well as void areas from blood vessels, lymph ducts, sinuses crypts, and villi. In the results, it is demonstrated that different tissue types can have a different matrix composition and thickness. Using this information, quantitative maps and elemental molarities for the lesser and trace elements Ca, Fe, and Zn are obtained.

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Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy

Whitlow,

Nagy,

Kuznetsov

et al. 2024

Physica Status Solidi (a)

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Baseline measurements in the assessment of ESS-specific radionuclide uptake by crops cultivated in Southern Sweden

Frost,

Hermansson,

Nagy

et al. 2024

Nuclear Instruments and Methods in Physics Research Section B:

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Evaluating Nondestructive Quantification of Composition Gradients in Metal–Organic Frameworks by MeV Ion Microbeam Analysis

Nagy,

Gschwind,

Ott

et al. 2024

Anal. Chem.

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Dynamic Analysis of major elements in biological tissue validating quantification of trace life elements in MeV ion beam microscopy

Cited by 3 publications

References 30 publications

Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy

Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy

Baseline measurements in the assessment of ESS-specific radionuclide uptake by crops cultivated in Southern Sweden

Evaluating Nondestructive Quantification of Composition Gradients in Metal–Organic Frameworks by MeV Ion Microbeam Analysis

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