2020
DOI: 10.1016/j.neuroscience.2019.10.008
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Dynamic Changes in Brain Glucose Metabolism and Neuronal Structure in Rats with Heart Failure

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Cited by 15 publications
(17 citation statements)
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“…Gray matter, an important part of the central nervous system, was consisted of a large number of neuronal bodies and their dendrites. As in our previous study [27], we also found out that the number of neurons and synapses significantly decreased and Nissl bodies disappeared in HF rats. In other words, our previous studies indirectly proved the decreased gray matter density of HF patients in clinical.…”
Section: Reduction In Volumesupporting
confidence: 87%
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“…Gray matter, an important part of the central nervous system, was consisted of a large number of neuronal bodies and their dendrites. As in our previous study [27], we also found out that the number of neurons and synapses significantly decreased and Nissl bodies disappeared in HF rats. In other words, our previous studies indirectly proved the decreased gray matter density of HF patients in clinical.…”
Section: Reduction In Volumesupporting
confidence: 87%
“…In animal studies, global cognition of animals was evaluated by passive avoidance tasks, active avoidance tasks, tail suspension test, forced swim test, sucrose preference test, open field tests, long-term potentiation recording, elevated plus maze, Y-maze test, object-in-place memory task, object oddity perceptual task and Morris water maze task(n = 13) (more details shown in Table 7). The reduction of learning [23] and memory in HF animals existed in six studies, and memory impairment manifested in short-term recognition memory [24], OiP memory [25], spatial memory [10,26,27], hippocampus-dependent memory [28]. [15,20,[29][30][31].…”
Section: Obvious Cognitive Dysfunction and Depression In Hfmentioning
confidence: 99%
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“…Male Sprague–Dawley rats (230–250 g) were obtained from Beijing Vital River Laboratory Animal Technology Co., Ltd. [Animal license number: SCXK (Beijing) 2016-0006]. HF after MI was induced surgically in rats by left anterior descending coronary artery (LAD) ligation as described previously ( Wu et al, 2013 ; Yang et al, 2019 ). Briefly, following anesthesia with sodium pentobarbital (40 mg/kg intraperitoneally) and intubation, a lateral thoracotomy was carried out to access the heart.…”
Section: Methodsmentioning
confidence: 99%
“…A 12-lead electrocardiogram was obtained before and 2 days after the surgery. Rats were anesthetized by injecting 40 mg/kg sodium pentobarbital, and echocardiography was performed as previously described [21] . Using a Vevo 2100 Imaging System Ultrasonic Diagnostic Equipment (VisualSonics, Canada) with a real-time high-frequency scan head of 15 MHz.…”
Section: Electrocardiographic and Echocardiographic Examinationmentioning
confidence: 99%