1993
DOI: 10.1002/aja.1001970107
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Dynamic changes in ovarian c‐kit and Steel expression during the estrous reproductive cycle

Abstract: Wand Steel mutant mice exhibit similar developmental defects in melanogenesis, haematopoiesis, and gametogenesis. Consistent with the cell autonomous and microenvironmental nature of W and S Z mutations, respectively, W encodes the c-kit receptor tyrosine kinase while Steel enclodes the Kit ligand. Both c-kit and Steel are expressed in various cells in which no corresponding mutant phenotype has yet been demonstrated. In the adult ovary, certain stromal-derived cells (theca and interstitial), as well as oocyte… Show more

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Cited by 123 publications
(83 citation statements)
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“…These results confirm earlier studies showing expression of c-Kit protein in oocytes and expression of its mRNA in oocytes and preovulatory granulosa cells (Horie et al 1993, Tanikawa et al 1998. Although several studies on mice have shown that c-Kit is confined to theca interna cells (Manova et al 1990, Horie et al 1991, Keshet et al 1991, Motro et al 1991, Motro & Bernstein 1993), we did not locate its expression in these cells in human ovarian biopsy samples. In this respect, our result is different from that reported by Ito et al (2001), who used RT-PCR and showed the presence of c-Kit mRNA in human ovarian theca and stroma cells.…”
Section: Discussionsupporting
confidence: 72%
See 1 more Smart Citation
“…These results confirm earlier studies showing expression of c-Kit protein in oocytes and expression of its mRNA in oocytes and preovulatory granulosa cells (Horie et al 1993, Tanikawa et al 1998. Although several studies on mice have shown that c-Kit is confined to theca interna cells (Manova et al 1990, Horie et al 1991, Keshet et al 1991, Motro et al 1991, Motro & Bernstein 1993), we did not locate its expression in these cells in human ovarian biopsy samples. In this respect, our result is different from that reported by Ito et al (2001), who used RT-PCR and showed the presence of c-Kit mRNA in human ovarian theca and stroma cells.…”
Section: Discussionsupporting
confidence: 72%
“…The expression of KL has been detected in granulosa cells in mouse ovaries, while c-Kit receptor is confined to the oocytes and theca interna cells (Manova et al 1990, Horie et al 1991, Keshet et al 1991, Motro et al 1991, Motro & Bernstein 1993. In contrast to mice, c-Kit protein and mRNA have been detected in both human oocytes and granulosa cells (Horie et al 1993, Tanikawa et al 1998.…”
Section: Reproduction (2006) 131 641-649mentioning
confidence: 99%
“…At the developmental stage, we found a strong KITC band-like pattern of expression in the former thecal layer. According to other groups, thecal cells of antral follicles express both KITC mRNA and KIT protein (Motro & Bernstein 1993, Parrott & Skinner 1997, Driancourt et al 2000, Brankin et al 2004. Obviously, the KIT expression persists after ovulation in the theca-derived capsule/septum in (Parrott & Skinner 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Growth factors that are expressed by granulosa cells which promote primordial to primary follicle transition include leukemia inhibitory factor (Arici et al 1997, Khalifa et al 1997 and KITL (Manova et al 1993, Motro & Bernstein 1993, Parrott & Skinner 1999, Nilsson & Skinner 2004. KITL receptors (c-kit) are present on oocytes and theca cells (Horie et al 1991, Manova et al 1993, Motro & Bernstein 1993.…”
Section: Introductionmentioning
confidence: 99%
“…KITL receptors (c-kit) are present on oocytes and theca cells (Horie et al 1991, Manova et al 1993, Motro & Bernstein 1993. KITL acts to recruit thecal cells from surrounding ovarian stroma during the primordial to primary follicle transition (Parrott & Skinner 2000).…”
Section: Introductionmentioning
confidence: 99%