Dynamic changes in quality of life, psychological status, and body image in women who underwent a mastectomy as compared with breast reconstruction: an 8-year follow up

Mudiyanselage, Sriyani Padmalatha Konara; Wu, Yi Lin; Kukreti, Shikha; Chen, Changchun; Lin, Chien Nan; Tsai, Yi‐Tseng; Fang, Su Ying; Wang, Jung‐Der; Ko, Nai Ying

doi:10.1007/s12282-022-01413-6

Cited by 8 publications

(5 citation statements)

References 70 publications

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“…Patients diagnosed at an early stage display a relative 5-year survival rate approaching 100% 3. Given that breast cancer survival rates are among the highest for cancers, ensuring quality of life for survivors is a primary concern, warranting consideration from the initial clinical consultation and treatment planning 4. Depression, a prevalent negative emotion, often shadows the lives of patients with breast cancer 5.…”

Section: Introductionmentioning

confidence: 99%

“… 3 Given that breast cancer survival rates are among the highest for cancers, ensuring quality of life for survivors is a primary concern, warranting consideration from the initial clinical consultation and treatment planning. 4 Depression, a prevalent negative emotion, often shadows the lives of patients with breast cancer. 5 Following a breast cancer diagnosis, a significant majority of patients will undergo surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

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Influence of low-dose esketamine on postoperative depressive symptoms in patients with breast cancer (EASE): study protocol for a randomised controlled trial

Wei,

Chen,

Zhu

et al. 2023

BMJ Open

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IntroductionDepressive symptoms have surfaced as the principal mental health concern among patients with breast cancer, with surgical interventions potentially exacerbating these symptoms and adversely influencing clinical outcomes. This study protocol is designed to investigate the efficacy of low-dose esketamine administered perioperatively on depressive symptoms in patients with breast cancer. It also aims to illuminate the potential neurobiological underpinnings of this effect.Methods and analysisThis research represents a single-centre, prospective, randomised, double-blind, placebo-controlled study. The trial anticipates enrolling 108 female patients exhibiting mild-to-severe depressive symptoms who are slated for radical mastectomy. Through stratified randomisation, eligible patients will be systematically assigned to either the esketamine group (0.25 mg/kg) or placebo group (0.9% saline) in a 1:1 ratio. The primary outcome is the response rate at the third postoperative day. Secondary outcomes encompass the remission rate, depression-related scores, depression severity and safety-related endpoints. Tertiary (exploratory) outcomes involve alterations in brain-derived neurotrophic factor and resting-state functional brain connectivity.Ethics and disseminationThe Clinical Trial Ethics Committee at The First Affiliated Hospital of Anhui Medical University has conferred ethical approvals for this trial (approval number: PJ2023-05-25). Results from this trial will be disseminated in peer-reviewed journals and presented at professional symposiums.Trial registration numberChinese Clinical Trials Registry (ChiCTR2300071062).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of low-dose esketamine on postoperative depressive symptoms in patients with breast cancer (EASE): study protocol for a randomised controlled trial

Wei,

Chen,

Zhu

et al. 2023

BMJ Open

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“…Breast reconstruction post-mastectomy has reported improved psychological outcomes [ 1 ], with autologous abdominal tissue becoming increasingly common in specialist UK practice [ 2 ]. It is more robust, natural in appearance, and carries lower morbidity with the administration of adjuvant radiotherapy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Duration of Postoperative Antibiotics in Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis

Aldarragi¹,

Farah²,

Warner³

et al. 2023

Cureus

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Although prophylactic antibiotic use following autologous breast reconstruction post-mastectomy is a common practice, there is no consensus in the literature regarding its duration. Antibiotic stewardship is important to minimise multi-resistant organisms as well as mitigate the associated side effects. Currently, there are no published guidelines regarding the duration of prophylactic antibiotics in autologous breast reconstruction surgery following mastectomy. The authors searched the online literature regarding the administration of antibiotics for autologous breast reconstruction surgery post-mastectomy. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. The primary outcome measure was the incidence of surgical site infections (SSIs). Three studies met the inclusion criteria and included a total of 1,400 patients. Overall, 101 (7.2%) SSIs were observed. There was no significant difference in the rate of SSIs when comparing the use of antibiotics for less than or longer than 24 hours postoperatively (odds ratio = 1.434, p = 0.124). There is no significant difference between SSIs with the use of antibiotics for longer than 24 hours when compared to less than 24 hours. Further studies in the form of randomised controlled trials are required to assess the effects of prophylactic antibiotic duration in autologous breast reconstruction following mastectomy.

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“…An increasing number of patients with breast cancer opt for reconstruction after mastectomy to restore the shape of the breast and limit the potential adverse psychological effects after mastectomy. 1 Breast reconstruction can be performed immediately after surgery [immediate breast reconstruction (IBR)] or later (delayed breast reconstruction), with implant (implant-based breast reconstruction) 2 or flap. IBR offers a native inframammary fold and pliable skin envelope that results in a more natural appearance and limits the psychological impact of surgery.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Antibiotics for Deep Inferior Epigastric Perforator Flap Breast Reconstruction: A Comparison between Three Different Duration Approaches

Changchien

Fang

Tsai

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: There is no consensus on the duration of prophylactic antibiotic use for autologous breast reconstruction after mastectomy. We attempted to standardize the use of prophylactic antibiotics after mastectomy using a deep inferior epigastric perforator flap for the breast reconstruction procedure. Methods: This retrospective case series included 108 patients who underwent immediate breast reconstruction with a deep inferior epigastric perforator flap at the Ditmanson Medical Foundation Chia-Yi Christian Hospital between 2012 and 2019. Patients were divided into three groups based on the duration of prophylactic antibiotic administration (1, 3, and >7 days) for patients with drains. Data were analyzed between January and April 2021. Results: The prevalence of surgical site infection in the breast was 0.93% (1/108), and in the abdomen it was 0%. The patient groups did not differ by age, body mass index, smoking status, or neoadjuvant chemotherapy. Only one patient experienced surgical site infection in the breast after half-deep necrosis of the inferior epigastric perforator flap. There were no significant differences in surgical site infection based on the duration of prophylactic antibiotic use. The operation time, methods of breast surgery, volume of fluid drainage in the first 3 days of the abdominal and breast drains, and day of removal of the abdominal and breast drains did not affect surgical site infection. Conclusion:Based on these data, we do not recommend extending prophylactic antibiotics beyond 24 hours in deep inferior epigastric perforator reconstruction.

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Dynamic changes in quality of life, psychological status, and body image in women who underwent a mastectomy as compared with breast reconstruction: an 8-year follow up

Cited by 8 publications

References 70 publications

Influence of low-dose esketamine on postoperative depressive symptoms in patients with breast cancer (EASE): study protocol for a randomised controlled trial

Influence of low-dose esketamine on postoperative depressive symptoms in patients with breast cancer (EASE): study protocol for a randomised controlled trial

The Duration of Postoperative Antibiotics in Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis

Prophylactic Antibiotics for Deep Inferior Epigastric Perforator Flap Breast Reconstruction: A Comparison between Three Different Duration Approaches

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