Dynamic contrast-enhanced and diffusion-weighted MRI of estrogen receptor-positive invasive breast cancers: Associations between quantitative MR parameters and Ki-67 proliferation status

Abstract

4 J. Magn. Reson. Imaging 2017;45:94-102.

Use of diffusion kurtosis imaging and quantitative dynamic contrast‐enhanced MRI for the differentiation of breast tumors

“…4 Furthermore, ROC analysis suggests that K trans had higher sensitivity than k ep in diagnosing breast cancers at equal accuracy, consistent with that in other studies. 19,22,23 By contrast, Li et al 24 observed that k ep might better depict tumor capillary permeability than K trans because K trans may tend to be influenced by conditions influencing blood perfusion. However, k ep is not confounded by these factors.…”

Diffusion‐weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2– breast cancers

“…The prognostic value of breast tumor MRI characteristics is an emerging area of research. Several studies have recently reported ADC measures to be associated with tumor grade and proliferation . However, these prior DWI studies have not focused specifically on hormone receptor‐positive, HER2‐negative invasive breast cancers, the most common but heterogeneous group of breast cancers, for which chemotherapy recommendation is variable in practice.…”

“…17 While DCE-MRI provides information about tumor vascularity, DWI reflects water mobility in tissue, characterizing tumor cellularity. Recent studies have shown DWI measurements to correlate with prognostic markers such as Nottingham grade, 18,19 Ki-67 score, [20][21][22][23] and expression of HER2, 22,24 and hormonal receptors 21,24 in invasive breast cancer. However, few studies specifically evaluate ER-positive cancers, 25 and to our knowledge only one published study to date has specifically investigated DWI as a potential predictor of RS.…”

DWI in the Assessment of Breast Lesions

“…Within invasive disease, a number of studies have shown ADC values to negatively correlate with tumor grade [17–21]. A similar correlation was seen with tumor proliferation, using Ki-67 index as a marker [13, 21–26]. The ability to detect more aggressive tumors may aid in consideration of neoadjuvant treatment prior to surgery.…”