Dynamic Contrast Enhanced, Pelvic Phased Array Magnetic Resonance Imaging of Localized Prostate Cancer for Predicting Tumor Volume: Correlation With Radical Prostatectomy Findings

Villers, Arnauld; Puech, Philippe; Mouton, Damien; Leroy, Xavier; Ballereau, Charles; Lemaître, L.

doi:10.1016/j.juro.2006.08.007

Cited by 347 publications

(209 citation statements)

References 21 publications

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“…Reports on DCE MRI performance in the TZ are controversial. Some published results 14,19 suggested indeed a potential value of DCE in the TZ, although other studies failed. 20,21 In our series, ADC (provided by DW imaging) was the only parameter that improved performance when combined to T2W.…”

Section: Discussionmentioning

confidence: 99%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

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To study the staging accuracy of multiparametric magnetic resonance imaging (MRI) in patients showing unilateral low-risk cancer on prostate biopsy. A total of 58 consecutive patients with lowrisk cancer (D'Amico classification) and unilateral cancer involvement on prostate biopsies were included prospectively. All patients underwent multiparametric endorectal MRI before radical prostatectomy, including T2-weighted (T2W), diffusion-weighted (DW) and dynamic contrast enhanced (DCE) sequences. Each gland was divided in eight octants. Tumor foci 40.2 cm 3 identified on pathological analysis were matched with MRI findings. Pathological examination showed tumor foci 40.2 cm 3 in 50/58 glands (86%), and bilateral tumor (pathological stageXpT2c) in 20/58 (34%). For tumor detection in the peripheral zone (PZ), T2W þ DWI þ DCE performed significantly better than T2W þ DWI and T2W alone (Po0.001). In the transition zone (TZ), only T2W þ DWI performed better than T2W alone (P ¼ 0.02). With optimal MR combinations, tumor size was correctly estimated in 77% of tumor foci involving more than one octant. Bilateral tumors were detected in 80% (16/20) of cases. In patients with unilateral low-risk prostate cancer on biopsy, multiparametric MRI can help to predict bilateral involvement. Multiparametric MRI may therefore have a prognostic value and help to determine optimal treatment in such patients.

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Section: Discussionmentioning

confidence: 99%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

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“…In DCE-MRI, the distribution of the contrast agent is repeatedly evaluated, allowing the evaluation of the tumor microcirculation in vivo and enabling the malignancy or benignancy of the tumor to be quantitatively distinguished (6,7). A number of previous studies have shown the diagnostic value of DCE-MRI for prostate cancer (8)(9)(10), for the evaluation of pancreatic cancer (11), and for evaluating the efficacy of cancer drugs (12)(13)(14). Only one previous study has used DCE-MRI to evaluate the tumor drug response in colorectal cancer (15), and, at present, no published studies have been concerned with the diagnostic value of DCE-MRI for rectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Chen

et al. 2016

Molecular and Clinical Oncology

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Abstract. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a novel imaging modality that can be used to reflect the microcirculation, although its value in diagnosing rectal cancer is unknown. The present study aimed to explore the clinical application of DCE-MRI in the preoperative diagnosis of rectal cancer, and its correlation with tumor differentiation. To achieve this, 40 pathologically confirmed patients with rectal cancer and 15 controls were scanned using DCE-MRI. The Tofts model was applied to obtain the perfusion parameters, including the plasma to extravascular volume transfer (Ktrans), the extravascular to plasma volume transfer (Kep), the extravascular fluid volume (Ve) and the initial area under the enhancement curve (iAUC). Receiver-operating characteristic (ROC) curves were plotted to determine the diagnostic value. The results demonstrated that the time-signal intensity curve of the rectal cancer lesion exhibited an outflow pattern. The Ktrans, Kep, Ve, and iAUC values were higher in the cancer patients compared with controls (P<0.05). The intraclass correlation coefficients of Ktrans, Kep, Ve and iAUC, as measured by two independent radiologists, were 0.991, 0.988, 0.972 and 0.984, respectively (all P<0.001), indicating a good consistency. The areas under the ROC curves for Ktrans and iAUC were both >0.9, resulting in a sensitivity and specificity of 100% and 93.3% for Ktrans, and of 92.5%, and 93.3% or 100%, for iAUC, respectively. In the 40 rectal cancer cases, there was a moderate correlation between Ktrans and iAUC, and pathological differentiation (0.365 years old, and rectal cancer occurs rarely in patients who are under 40 years of age; in addition, men are predominantly affected (2). Probable risk factors include age, male gender, colon polyps, a history of colorectal cancer, a history of inflammatory bowel disease, hereditary syndromes, lifestyle factors (diet, alcohol, obesity, sedentary lifestyle and smoking), and a history of diabetes mellitus (1). Rectal cancer is usually managed using a combination of surgery, chemotherapy, targeted therapy and radiation therapy (3). The five-year survival rates following surgical resection are 85-95% for stage I, 60-80% for stage II, and 30-60% for stage III cancer. With the aging of the Chinese society and a Westernization of the diet, the incidence of rectal cancer in China is increasing (4). Therefore, finding novel means to efficiently detect and diagnose rectal cancer are required.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a relatively novel imaging modality that demonstrates the capillary blood flows (5,6). In DCE-MRI, the distribution of the contrast agent is repeatedly evaluate...

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“…While defining the anatomic extent of prostate cancer at presentation remains under investigation (5) and important in guiding management, the ability to define tumor response to neoadjuvant therapy based on imaging remains a high priority because it provides the early identification of men with disease that is resistant to current standards of care. After these men are identified, they would be eligible for entry to randomized clinical trials designed to evaluate the impact on survival of adding therapies aimed at overcoming treatment resistance to the current standards of practice.…”

Section: Introductionmentioning

confidence: 99%

Tumor Volume Changes on 1.5 Tesla Endorectal MRI During Neoadjuvant Androgen Suppression Therapy for Higher-Risk Prostate Cancer and Recurrence in Men Treated Using Radiation Therapy Results of the Phase II CALGB 9682 Study

D’Amico

Halabi

Tempany

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Purpose-We prospectively determined whether the change in tumor volume (TV) during 2 months of neoadjuvant androgen suppression therapy (nAST) measured using conventional 1.5 Tesla endorectal magnetic resonance imaging (eMRI) was associated with the risk of recurrence after radiation (RT) and 6 months of AST. 1997 and 2001, 180 men with clinical stage T1c-T3cN0M0 adenocarcinoma of the prostate were registered. Fifteen were found to be ineligible and the institutional MR radiologist could not assess the TV in 32, leaving 133 for analysis. Multivariable Cox regression analysis was used to assess whether a significant association existed between eMRIdefined TV progression during nAST and time to recurrence adjusting for prostate-specific antigen (PSA) level, Gleason score (8 to 10 or 7 vs. 6 or less) and stage (T3 vs. T1-2). Patients and Methods-BetweenResults-After a median follow up of 6.7 years and adjusting for known prognostic factors, there was a significant increase in the risk of PSA failure (HR, 2.3 [95% CI, 1.1-4.5; p = 0.025) in men with eMRI-defined TV progression during nAST. Specifically, adjusted estimates of PSA failure were significantly higher (p = 0.032) in men with, compared with men without, eMRI-defined TV progression reaching 38% vs. 19%, respectively, by 5 years. Conclusion-Eradicating

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Dynamic Contrast Enhanced, Pelvic Phased Array Magnetic Resonance Imaging of Localized Prostate Cancer for Predicting Tumor Volume: Correlation With Radical Prostatectomy Findings

Cited by 347 publications

References 21 publications

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

Tumor Volume Changes on 1.5 Tesla Endorectal MRI During Neoadjuvant Androgen Suppression Therapy for Higher-Risk Prostate Cancer and Recurrence in Men Treated Using Radiation Therapy Results of the Phase II CALGB 9682 Study

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