Dynamic Electroporation Model Evaluation on Rabbit Tissues

Weinert, Rodolfo Lauro; Knabben, Marcel Augusto; Pereira, Eduardo Manoel; Garcia, Christian Evangelista; Ramos, Alexandre Moraes

doi:10.1007/s10439-021-02816-w

Cited by 4 publications

(1 citation statement)

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“…One example is assessing skin electroporation by assessing the electric field effects and diffusion from length scales ranging from the skin to an individual membrane by using molecular dynamics [97]. Weinert et al developed dynamic, multiphysics simulation of electroporation of various tissues in rabbits, although they did not go to the dynamics of electroporation at the pore level [98]. In addition to PEFs, RF and microwave radiation may also penetrate the body and induce multiphysics phenomena that may influence TMP and cellular function [99].…”

Section: Introductionmentioning

confidence: 99%

A Simplified Electrical-Based Model for Electroporation Dynamics

Loveless,

Wyss,

MIlestone

et al. 2024

IEEE Access

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Calculating pulsed electric field (PEF)-induced pore formation using the Smoluchowski equation (SME) can be computationally expensive, even when reduced to the asymptotic SME (ASME). These issues are exacerbated when incorporating additional physical phenomena, such as membrane temperature gradients or shock waves, or incorporating pore formation into multiscale models starting from an external stimulus at the organism level. This study presents a rapid method for calculating the membranelevel effects of PEFs by incorporating a semi-empirical equation for transmembrane potential (TMP)dependent membrane conductivity into a single-shell model for calculating the TMP. The TMP calculated using this approach and the ASME agreed well for a range of electric field strengths for various PEF durations and AC frequencies below and above the threshold for pore formation. These results demonstrate the feasibility of rapidly predicting TMP, which is easily measured, during pore formation strictly from electrical properties and dynamics without needing to explicitly calculate pore dynamics, as required when using the SME and ASME.

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Section: Introductionmentioning

confidence: 99%