Dynamic Factors Controlling Targeting Nanocarriers to Vascular Endothelium

Muzykantov, Vladimir R.; Radhakrishnan, Ravi; Eckmann, David M.

doi:10.2174/138920012798356916

Cited by 31 publications

(39 citation statements)

References 139 publications

(291 reference statements)

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“…Bull provided descriptions of microbubble designs and the fluid microdynamics induced by oscillating microbubbles [23]. Several relevant reviews on techniques for targeting drug-loaded vesicles to the endothelium have also been published [24–26]. This review focuses on US-mediated drug delivery for the treatment of cardiovascular disease, both updating and expanding the aforementioned reviews and focusing on treatment of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-mediated drug delivery for cardiovascular disease

Sutton

Haworth

Pyne‐Geithman

et al. 2013

Expert Opinion on Drug Delivery

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Introduction Ultrasound (US) has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, or US contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi or direct drugs to optimal locations for delivery. Areas covered The present review summarizes investigations that have provided evidence for US-mediated drug delivery as a potent method to deliver therapeutics to diseased tissue for cardiovascular treatment. In particular, the focus will be on investigations of specific aspects relating to US-mediated drug delivery, such as delivery vehicles, drug transport routes, biochemical mechanisms and molecular targeting strategies. Expert opinion These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery and new US technologies. Successful implementation of US-mediated drug delivery has the potential to change the way many drugs are administered systemically, resulting in more effective and economical therapeutics, and less-invasive treatments.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-mediated drug delivery for cardiovascular disease

Sutton

Haworth

Pyne‐Geithman

et al. 2013

Expert Opinion on Drug Delivery

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show abstract

“…Bull provided descriptions of microbubble designs and the fluid microdynamics induced by oscillating microbubbles [23]. Several relevant reviews on techniques for targeting drug-loaded vesicles to the endothelium have also been published [24][25][26]. This review focuses on US-mediated drug delivery for the treatment of cardiovascular disease, both updating and expanding the aforementioned reviews and focusing on treatment of cardiovascular diseases.…”

Section: Us Technology For Therapeutic Delivery and Monitoringmentioning

confidence: 99%

Ultrasound-Mediated Drug Delivery for Cardiovascular Disease

Holland

2017

Ultrasound in Medicine & Biology

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Introduction-Ultrasound (US) has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. These effects can be mediated by mechanical oscillations of circulating microbubbles, or US contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi or direct drugs to optimal locations for delivery.Areas covered-The present review summarizes investigations that have provided evidence for US-mediated drug delivery as a potent method to deliver therapeutics to diseased tissue for cardiovascular treatment. In particular, the focus will be on investigations of specific aspects relating to US-mediated drug delivery, such as delivery vehicles, drug transport routes, biochemical mechanisms and molecular targeting strategies.Expert opinion-These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery and new US technologies. Successful implementation of US-mediated drug delivery has the potential to change the way many drugs are administered systemically, resulting in more effective and economical therapeutics, and lessinvasive treatments.

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“…1, 9, 13-18 The intracellular and extracellular environments of all living things are water-based solutions and gels separated by lipoprotein membranes into subcellular organelles and cells. Effective delivery of the particles depends on their remaining stable in an aqueous (blood and tissue fluids) or gaseous (inspired or body surface air) environment until they can be selectively and, hopefully, specifically attached to their target.…”

Section: 0 Physical and Chemical Propertiesmentioning

confidence: 99%

“…1, 21-23 These mechanisms are influenced by the particle size and shape and the chemical composition and electrical charge of the particle surface. 9 [Figure 2]…”

Section: Endocytosis: Transport Of Nanoparticles Into the Targetedmentioning

confidence: 99%

Nanoparticles in medicine: selected observations and experimental caveats

Thomsen¹,

Pearce

Giustini

et al. 2013

SPIE Proceedings

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Medically useful nanoparticles measure 1-100 nm in at least one dimension and are engineered and manufactured for specific diagnostic and treatment applications. Most nanoparticles used currently used in medicine are engineered and manufactured for specific purposes. Medically significant nanoparticles are composed of a 1) central core that is usually the medically active component, 2) one or more layers of organic or inorganic materials that forms a capsule (corona) covering the core and 3) an outer surface layer that interacts with the environment and/or targeted cells and tissues. Effective nanoparticle function in the living, intact animal or human requires electrochemical stability necessary to bypass the reticuloendothelial system (RES) and avoid filtration through the renal glomerulus into the urine. Nanoparticles are present in “natural” as well as the manufacturing and clinical environments thus could pose as significant toxins because of their small sizes, their chemical and drug content and potential effect of causing long term disease including allergies, chronic inflammation and cancer. Currently published studies have focused on the effects of nanoparticles on cells in the extremely artificial environments of cell cultures. More clinical and preclinical studies documenting the short term and long term effects nanoparticle in the intact experimental animal and human are needed.

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Dynamic Factors Controlling Targeting Nanocarriers to Vascular Endothelium

Cited by 31 publications

References 139 publications

Ultrasound-mediated drug delivery for cardiovascular disease

Ultrasound-mediated drug delivery for cardiovascular disease

Ultrasound-Mediated Drug Delivery for Cardiovascular Disease

Nanoparticles in medicine: selected observations and experimental caveats

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