Dynamic interaction processes of rare earth metal mixtures in terrestrial organisms interpreted by toxicokinetic and toxicodynamic model

Gong, Bing; He, Erkai; Gestel, Cornelis A.M. van; Tang, Yetao; Yang, Wenjun; Yang, Jing; Li, Ye; Qiu, Hao

doi:10.1016/j.jhazmat.2021.126281

Cited by 17 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The estimated uptake (K u )/ elimination (K e ) rate constants in snails based on shoot concentrations were 0.030−1.6 kg shoot kg snail −1 day −1 /0.12−1.8 day −1 for LREE, 0.010−0.37 kg shoot kg snail −1 day −1 /0.010−1.2 day −1 for MREE, and 0.010−2.88 kg shoot kg snail −1 day −1 /0.060− 1.5 day −1 for HREE (Figure 4A). These values are comparable to the K u of 0.24−3.7 L kg −1 day −1 and K e of 0.082−1.5 day −1 reported for the toxicokinetics of REEs in enchytraeids exposed in a soil solution−quartz sand system 10,42 but much higher than the rate constants for enchytraeids (0.000821− 0.122 kg soil kg worm −1 day −1 for K u and 0.0224−0.136 day −1 for K e ) exposed to natural field soil. 43 This suggests that REEs are more bioaccessible to snails via trophic exposure.…”

Section: Trophic Transfer and Ree Profiles In Snailssupporting

confidence: 85%

Trophic Transfer and Toxic Potency of Rare Earth Elements along a Terrestrial Plant–Herbivore Food Chain

Li,

Qiu,

van Gestel

et al. 2024

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Extensive rare earth element (REE) mining activities have caused REE contamination of ambient agricultural soils, posing threats to associated food webs. Here, a simulated lettuce−snail food chain was conducted to evaluate the trophic transfer characteristics and the consequent effects of REEs on consumers. After 50-day exposure to soil, lettuce roots dosedependently accumulated 9.4−76 mg kg −1 REEs and translocated 3.7−20 mg kg −1 REEs to shoots. Snails feeding on REEcontaminated shoots accumulated 3.0−6.7 mg kg −1 REEs with trophic transfer factors of 0.20−0.98, indicating trophic dilution in the lettuce−snail system. REE profiles in lettuce and snails indicated light REE (LREE) enrichment only in snails and the varied REE profiles along the food chain. This was corroborated by toxicokinetics. Estimated uptake (K u ) and elimination (K e ) parameters were 0.010−2.9 kg shoot kg snail −1 day −1 and 0.010−1.8 day −1 , respectively, with higher K u values for LREE and HREE. The relatively high K e , compared to K u , indicating a fast REE elimination, supports the trophic dilution. Dietary exposure to REEs dose-dependently affected gut microbiota and metabolites in snails. These effects are mainly related to oxidative damage and energy expenditure, which are further substantiated by targeted analysis. Our study provides essential information about REE bioaccumulation characteristics and its associated risks to terrestrial food chains near REE mining areas.

show abstract

Section: Trophic Transfer and Ree Profiles In Snailssupporting

confidence: 85%

Trophic Transfer and Toxic Potency of Rare Earth Elements along a Terrestrial Plant–Herbivore Food Chain

Li,

Qiu,

van Gestel

et al. 2024

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antagonistic interactions were found in C. reinhardtii based on transcriptomic data (Morel et al, 2021). Different mixture effects were described depending on the studied species (Romero-Freire et al, 2019;Bergsten-Torralba et al, 2020), mixture composition (Bergsten-Torralba et al, 2020 or exposure duration (Gong et al, 2021). In the current study, mixture effects were constant regardless of the studied species and medium composition.…”

Section: Ree Mixture Effectssupporting

confidence: 47%

Integrated environmental risk assessment of rare earth elements mixture on aquatic ecosystems

Lachaux

Cossu-Leguille

Poirier

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

Rare Earth elements (REE) have become essential in strategical sectors such as high- and green-technologies. Their increasing use in human activities worldwide leads to anthropogenic REE releases detectable in all compartments of the environment, transforming REE into emerging contaminants. However, their potential impacts on ecosystems are still poorly understood. In order to have a comprehensive understanding of REE ecotoxicology and to properly assess their environmental risk, we analysed the toxicity of three representative REE (neodymium Nd, gadolinium Gd, and ytterbium Yb). Following recommendations of the European Chemicals Agency, we assessed REE hazard by performing standard ecotoxicological tests on three freshwater species belonging to different trophic levels (algae, crustacean and fish). EC50 were calculated using different modes of expression of REE exposure concentration (based on nominal, measured total and dissolved concentrations) in order to more properly and accurately determine REE toxicity. In order to get closer to environmental conditions, we also tested the toxicity of REE in mixture because all of them occur naturally as such in the environment. Moreover, we added dissolved organic matter (DOM) in the test medium because DOM is ubiquitous and drives REE speciation in freshwater systems. The Results showed that DOM significantly reduced REE bioaccumulation and toxicity, probably by formation of non-bioavailable REE-DOM complexes. The algal species was the most sensitive to REE. Despite slight differences between Nd, Gd and Yb in behaviour and bioaccumulation, the three REE exhibited comparable toxicity and additive effects in mixture to all tested organisms. Thus, we considered REE as a uniform group and, for the first time, we used mixture toxicity values and environmental mixture concentrations to assess the risk of REE in freshwater (instead of considering different REE separately). The results revealed that the risk is currently limited to wastewater treatment plants, and industrial and mining activities, where released quantities of REE can induce severe damage to exposed freshwater organisms. However, the risks are likely more widespread in the future because anthropogenic REE releases are expected to increase.

show abstract

Modeling integrated biomarker response (IBR) index for the mussel Mytilus galloprovincialis (Lamark 1819) exposed to heavy metal mixture using the CCF design

2023

View full text Add to dashboard Cite

Dynamic interaction processes of rare earth metal mixtures in terrestrial organisms interpreted by toxicokinetic and toxicodynamic model

Cited by 17 publications

References 68 publications

Trophic Transfer and Toxic Potency of Rare Earth Elements along a Terrestrial Plant–Herbivore Food Chain

Trophic Transfer and Toxic Potency of Rare Earth Elements along a Terrestrial Plant–Herbivore Food Chain

Integrated environmental risk assessment of rare earth elements mixture on aquatic ecosystems

Modeling integrated biomarker response (IBR) index for the mussel Mytilus galloprovincialis (Lamark 1819) exposed to heavy metal mixture using the CCF design

Contact Info

Product

Resources

About