Dynamic MRI for bowel motility imaging–how fast and how long?

Jonge, Catharina S. de; Gollifer, R; Nederveen, Aart J.; Atkinson, David; Taylor, Stuart A.; Stoker, Jaap; Menys, Alex

doi:10.1259/bjr.20170845

Cited by 23 publications

(25 citation statements)

References 30 publications

(31 reference statements)

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“…No differences were found in the higher frequency range (11)(12)(13)(14)(15)(16)(17)(18)(19) contractions per minute), which primarily contains breathing motion, with an exception at 20 contraction per minute. No differences were found in the higher frequency range (11)(12)(13)(14)(15)(16)(17)(18)(19) contractions per minute), which primarily contains breathing motion, with an exception at 20 contraction per minute.…”

Section: Discussionmentioning

confidence: 93%

“…15,17 For inclusion in this study, we selected all participants that did not receive bowel preparation, resulting in the enrollment of sixteen healthy subjects. The study was designed to gain insight in healthy bowel motility quantified with MRI.…”

Section: Volunteersmentioning

confidence: 99%

“…The study was designed to gain insight in healthy bowel motility quantified with MRI. 15,17 For inclusion in this study, we selected all participants that did not receive bowel preparation, resulting in the enrollment of sixteen healthy subjects. Inclusion criteria included healthy, human volunteers who were willing to undergo minimal bowel preparation and MRI.…”

Section: Volunteersmentioning

confidence: 99%

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Assessment of fasted and fed gastrointestinal contraction frequencies in healthy subjects using continuously tagged MRI

Jonge

Sprengers

Rijn

et al. 2019

Neurogastroenterology Motil

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Background: Continuously tagged MRI during free breathing can assess bowel motility at frequencies as low as the slow wave, motility pattern range. This study aimed to evaluate noninvasive gastrointestinal-tagged MRI for small bowel motility assessment and to observe the physiological response to a 300-kcal meal challenge in healthy, overnight-fasted volunteers.Methods: After overnight fasting, 16 healthy subjects (7 women, mean age 25.5, range 19-37 years) underwent a free breathing, tagged MRI scan to capture small bowel motility. Each subject underwent a (a) baseline motility scan, (b) food challenge, (c) postchallenge scan, and (d) second postchallenge scan (after 20 minutes).Motility was quantified using a frequency analysis technique for measuring the spectral power of the strain, referred to as motility score. Motility score was assessed in 20 frequency intervals between 1 and 20 contractions per minute (cpm), and the data were analyzed with linear mixed-effect models. Key Result:The stimulation protocol demonstrated an immediate, food-induced, motility response in the low-frequency range (2-10 cpm), which is consistent with the stomach and small bowel frequency range (3-12 cpm). Conclusions and Inferences:This study shows that this MRI tagging technique is able to quantify the fasted-to-fed response to a 300-kcal meal challenge within the specific small bowel motility frequency range in healthy subjects. The food provocation MRI protocol provides a tool to explore the gut's response to a stimulus in specific motility frequency ranges in patients with gastrointestinal dysmotility and functional disorders. K E Y W O R D Sdynamic MRI, food challenge, motility, small bowel, SPAMM-tagged MRI This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 93%

Section: Volunteersmentioning

confidence: 99%

Section: Volunteersmentioning

confidence: 99%

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Assessment of fasted and fed gastrointestinal contraction frequencies in healthy subjects using continuously tagged MRI

Jonge

Sprengers

Rijn

et al. 2019

Neurogastroenterology Motil

Self Cite

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“…The short observation periods associated with breath‐hold protocols may seem inadequate to measure GI motility, but have shown good initial results and are very practical for clinical use. Recent work showed that in breath‐hold scanning, using a displacement mapping quantification technique (described below), a temporal resolution of at least 1 image per second and duration of 15 seconds is required for robust assessment of motility . Free‐breathing scans provide more information due to longer scanning times, but the breathing artifacts in the scans and the amount of data for processing still pose a burden to handle.…”

Section: Acquisition and Postprocessing Methodsmentioning

confidence: 99%

“…It has been automated for more repeatable and standardized results and it produces very easily readable color maps. The software has been used and validated in several studies 4,7,9,10,13,18,20,22,23,[25][26][27][39][40][41][42] and one software version is commercially available. 43 F I G U R E 1 This figure visualizes the described quantification techniques.…”

Section: Displacement Mappingmentioning

confidence: 99%

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

Jonge

Smout

Nederveen

et al. 2017

Neurogastroenterology Motil

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Dynamic magnetic resonance imaging (MRI) of gastrointestinal motility has developed rapidly over the past few years. The non-invasive and non-ionizing character of MRI is an important advantage together with the fact that it is fast and can visualize the entire gastrointestinal tract. Advances in imaging and quantification techniques have facilitated assessment of gastric, small intestinal, and colonic motility in a clinical setting. Dynamic MRI is used in the stomach to measure frequency and amplitude of antral contractions. [3][4][5] It is used for the small bowel to look at segmental and global motility using frequency measures and surrogate measures. [6][7][8][9][10][11][12] In the colon it has been applied to assess motion and velocity of contents, wall motion and to study motility using surrogate measures. 13-17 So far there has been a paucity of validation studies. To our knowledge there is only one study in which dynamic MRI findings were compared to manometry, demonstrating 100% correlation between visualized colonic movements and intraluminal pressure changes. 17 The clinical value of dynamic MRI is under evaluation for pathologies like inflammatory bowel disease (IBD), chronic intestinal pseudo-obstruction (CIPO) and constipation. they quantified small bowel motility using dynamic MRI. 18 In this review we discuss the challenges and opportunities in evaluating gastrointestinal motility with dynamic MRI. The first part of this review summarizes the technical aspects of the dynamic MRI technique; the second part discusses the observations made by applying the described

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Quantitative Magnetic Resonance Imaging (qMRI) of the Small Bowel in Crohn's Disease: State‐of‐the‐Art and Future Directions

Sakai,

Bray,

Taylor

2024

Magnetic Resonance Imaging

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Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract in which repeated episodes of acute inflammation may lead to long‐term bowel damage. Cross‐sectional imaging is used in conjunction with endoscopy to diagnose and monitor disease and detect complications. Magnetic resonance imaging (MRI) has demonstrable utility in evaluating inflammatory activity. However, subjective interpretation of conventional MR sequences is limited in its ability to fully phenotype the underlying histopathological processes in chronic disease. In particular, conventional MRI can be confounded by the presence of mural fibrosis and muscle hypertrophy, which can mask or sometimes mimic inflammation. Quantitative MRI (qMRI) methods provide a means to better differentiate mural inflammation from fibrosis and improve quantification of these processes. qMRI may also provide more objective measures of disease activity and enable better tailoring of treatment. Here, we review quantitative MRI methods for imaging the small bowel in CD and consider the path to their clinical translation.Level of Evidence2Technical EfficacyStage 2

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Dynamic MRI for bowel motility imaging–how fast and how long?

Cited by 23 publications

References 30 publications

Assessment of fasted and fed gastrointestinal contraction frequencies in healthy subjects using continuously tagged MRI

Assessment of fasted and fed gastrointestinal contraction frequencies in healthy subjects using continuously tagged MRI

Evaluation of gastrointestinal motility with MRI: Advances, challenges and opportunities

Quantitative Magnetic Resonance Imaging (qMRI) of the Small Bowel in Crohn's Disease: State‐of‐the‐Art and Future Directions

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