2020
DOI: 10.1096/fasebj.2020.34.s1.04517
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Dynamic Phosphorylation of Yeast eIF4A Drives Changes in Gene Expression that Couple Protein Synthesis with Cell Division

Abstract: The eukaryotic translation initiation factor 4A (eIF4A) supports mRNA recruitment to the ribosomal preinitiation complex through activity of its conserved DEAD‐box RNA helicase motif. Interestingly, in plants eIF4A is differentially phosphorylated near the DEAD motif during various phases of the cell cycle by CDKA, lowering translation activity during mitosis ( Bush et al., 2016). The same Threonine residue of yeast eIF4A (T146) is present in a consensus CDK1/CDKA/Cdc28 motif, and is highly phosphorylated in l… Show more

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