Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations

Using strong cation exchange simulated moving bed (SMB) chromatography, a nitrogen-phosphate-potassium (NPK) fertilizer is produced in a cost-effective manner. The SMB process operated in a non-traditional way is divided into production and regeneration sections for exclusion of undesirable ions, and composed of six zones including two wash-water zones. This paper addresses modeling, simulation and optimization studies on this ionexchange SMB process, based upon experimental data obtained both from a pilot plant and an industrial plant. This study aims to optimize the SMB process in terms of i) maximization of productivity in the production section and ii) minimization of wash-water consumption, thereby resulting in i) increasing the profit and ii) reducing the overall operating cost in the downstream processing, respectively. The two objectives are sequentially treated within the framework of a multi-level optimization procedure (MLOP) which includes two pre-optimization levels, a productivity maximization level and a desorbent (or wash-water) consumption minimization level. In this optimization study, it is demonstrated that wash-water consumption can be reduced by 5 % at a 5% higher productivity.

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“…(2)- (5). 27 The cyclic stationary state is shown for resin concentration distributions over the columns in Fig. 7.…”

Section: Industrial Plant Resultsmentioning

confidence: 99%

Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Lim

Jørgensen

2007

Ind. Eng. Chem. Res.

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“…An alternative method is applying correlations using the Péclet (Pe) and the Reynolds (Re) number. Both ways are good engineering practice e.g., in chromatography [32][33][34].…”

Section: Process Modelingmentioning

confidence: 99%

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Sixt

Strube

2017

Processes

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Abstract:In this study, the solvent based extraction of artemisinin from Artemisia annua L. using acetone in percolation mode is compared to the method of pressurized hot water extraction. Both techniques are simulated by a physico-chemical process model. The model as well as the model parameter determination, including the thermal degradation of artemisinin are shown and discussed. For the conventional extraction, a solvent screening is performed considering various organic solvents. A temperature screening is presented for the systematic design of the pressurized hot water extraction. The best temperature with regards to thermal decomposition and high productivity was found to be 80 • C. Both, conventional percolation and Pressurized Hot Water Extraction (PHWE) are suitable for the extraction of artemisinin. The extraction curves show a high conformity with the simulation results.

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“…The particle mass balance including mass transfer resistance is adopted from the work of Strube et al (21): …”

Section: Mathematical Modelingmentioning

confidence: 99%

“…Mathematical modeling of continuous chromatographic separations has been covered thoroughly in the works of Dünnebier et al (19), Strube and Schmidt-Traub (20) and Strube et al (21). The modeling of the SMB system has been handled by two main approaches: (1) as an equivalent true-moving system (TMB) where the solid and fluid velocities are involved and the boundary conditions of the chromatography columns are independent of time, and (2) as a simulated counter-current system where there are several sections with a number of chromatography columns in each, and whose boundary conditions change with time (22).…”

Section: Mathematical Modelingmentioning

confidence: 99%

Optimal Economic Design and Operation of Single‐ and Multi‐column Chromatographic Processes

Chan

Titchener‐Hooker

Sørensen

2008

Biotechnology Progress

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Single-column chromatography is widely used in the biopharmaceutical industries, although multi-column alternatives in the form of simulated moving bed (SMB) processes are now emerging. It may be difficult, however, to determine which column alternative will be best suited for a given application, and this work sets out to address this issue. A systematic approach is presented that is based on a full economic appraisal of each process alternative based on an optimization of the net annual profit. Single-column processes with and without recycling are considered, as are both the SMB and the Varicol process. The cyclic steady state for the SMB and Varicol processes is determined directly by complete discretization. The approach is applied to a case study based on a linear isotherm where it is found that for this particular system, a recycling policy is not necessary for the single column. When comparing the single-column process with the multi-column alternatives, the single column is the most economical provided the life time of the project is short; however, the economic benefits of the more capital-intensive multi-column processes are greater if the life time of the project is over 5 years. The SMB process is found to perform marginally better than the Varicol process over 15 years; however, this may be because not all extra degrees of freedom for the Varicol process were considered.

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Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations

Cited by 50 publications

References 10 publications

Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Optimization of a Six-Zone Simulated-Moving-Bed Chromatographic Process

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Optimal Economic Design and Operation of Single‐ and Multi‐column Chromatographic Processes

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