The unique combination of physical and optical properties of silica (core)/gold (shell) nanoparticles (gold nanoshells) makes them especially suitable for biomedicine. Gold Nanoshells have been used from high-resolution in vivo imaging to in vivo photothermal tumor treatment. Furthermore, the reduced size and large scattering cross section of Gold Nanoshells in the second biological window (1000-1700 nm) make them also especially adequate for molecular optical coherence tomography (OCT). In this work, we demonstrate how, after adequate functionalization, gold nanoshells in combination with clinical OCT systems are capable of imaging damage in the myocardium after an infarct. Since both inflammation and apoptosis are two of the main mechanisms underlying myocardial damage after ischemia, such damage imaging is achieved by endowing Gold Nanoshells with selective affinity for the inflammatory marker Intercellular Adhesion Molecule 1 (ICAM-1), and the apoptotic marker phosphatidylserine (PS). The results here presented constitute a first step towards a fast, safe, and accurate diagnosis of damaged tissue within infarcted hearts at the molecular level by means of the highly sensitive OCT interferometric technique.