Dynamic supraparticles for the treatment of age-related diseases

Liao, Hongwei; Liang, Zeyu; Wang, Nan; Wei, Min; Chen, Ying; Li, Fangyuan; Ling, Daishun

doi:10.1016/j.scib.2019.08.003

Cited by 10 publications

(2 citation statements)

References 156 publications

(175 reference statements)

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“…1d and Supplementary Fig. 4) [32][33][34] . In contrast, the control NP 1 nanoparticles with no end groups failed to form coacervates via fluid-fluid phase separation, thereby confirming the importance of the physical interactions of end groups to the formation of NPA coacervates (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 97%

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

et al. 2021

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A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable of prolonged retention in the gastrointestinal tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled coacervate demonstrates significant pH- and salt-independent structural stability and forms a physically adhesive coating on a large surface area of intestinal tract with an extended residence time of more than 2 days to mediate the sustained release of preloaded water-soluble small molecule drugs in vivo. The orally administered drug-laden nanoparticle-assembled coacervate significantly mitigates the symptoms of inflammatory bowel disease, restores the diversity of gut microbiota, reduces systemic drug exposure, and improves the therapeutic efficacy in a rat acute colitis model compared with the oral administration of the same amount of drug in solution form. We suggest that the nanoparticle-assembled coacervate provides a promising drug delivery platform for management and treatment of numerous gastrointestinal diseases where controlled drug release with extended residence time is desired.

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Section: Resultsmentioning

confidence: 97%

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

et al. 2021

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“…Biocompatibility is another essential consideration for photonic nanomedicines in biomedical applications [64][65][66]. Therefore, we assessed the hemolysis and cytotoxicity of SnNSs@PEG.…”

Section: Biocompatibility Of Snnss@pegmentioning

confidence: 99%

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Ouyang

Zhang

et al. 2021

Nano-Micro Lett.

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Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

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Innovative Applications and Perspectives of Surface‐Enhanced Raman Spectroscopy Technology in Biomedicine

Xu,

Xie,

Liu

et al. 2024

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Surface‐enhanced Raman spectroscopy (SERS) has become a revolutionary technique in the biomedical field, providing unparalleled sensitivity for the detection and characterization of biological samples. In this review, recent SERS innovations are comprehensively discussed, including advanced substrate materials, different SERS detection strategies, and multimodal approaches that combine SERS with other biotechnologies. Among them, the role of SERS in the accurate diagnosis of tumors is highlighted, which has promoted accurate molecular analysis and real‐time monitoring of treatment effects. In addition, the growing potential of SERS in the treatment of chronic diseases such as cardiovascular disease, diabetes, and neurodegenerative diseases is discussed. Moreover, the integration with microfluidic chip systems for precise single‐cell analysis is presented. To give a forward‐looking view, the key challenges faced by SERS technology are also proposed, and possible solutions to overcome these obstacles are provided.

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Dynamic supraparticles for the treatment of age-related diseases

Cited by 10 publications

References 156 publications

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Innovative Applications and Perspectives of Surface‐Enhanced Raman Spectroscopy Technology in Biomedicine

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