Dynamic Thiol/Disulfide Homeostasis in Predicting Adverse Neonatal Outcomes in Fetal Growth Restriction

Özler, Sibel; Öztaş, Efser; Guler, Basak Gumus; Erel, Özcan; Çağlar, Ali Turhan; Ergin, Merve; Danışman, Nuri

doi:10.1080/15513815.2019.1644686

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…The authors also suggested that decreased serum total thiol levels might be useful in predicting adverse neonatal outcomes. 18 A subsequent study supported these findings. 19 In another study conducted with preeclamptic pregnant women, it was shown that there was a decrease in serum thiol levels in pregnant women diagnosed with preeclampsia.…”

Section: Discussionmentioning

confidence: 69%

“…In a study examining serum thiol levels in pregnant women with fetal growth restriction, it was found that native thiol and total thiol levels were lower in the study group compared to the control group. The authors also suggested that decreased serum total thiol levels might be useful in predicting adverse neonatal outcomes 18 . A subsequent study supported these findings 19 .…”

Section: Discussionmentioning

confidence: 86%

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Evaluation of maternal serum thiol and ischemia‐modified albumin levels in cases of placenta previa: A case–control study in a tertiary center

Denizli,

Tanacan,

Bastemur

et al. 2024

J of Obstet and Gynaecol

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AimWe aim to compare the maternal serum thiol and ischemia‐modified albumin (IMA) levels between pregnant women with placenta previa and those with uncomplicated pregnancies and to determine whether changes in these levels were useful in predicting cases of abnormally invasive placenta (AIP).MethodsFifty‐five pregnant women diagnosed with placenta previa according to the diagnostic criteria (case group) were compared to 100 women with uncomplicated pregnancies of similar demographic characteristics (control group). The patients with placenta previa were further divided into two subgroups: AIP (n = 20) and placenta previa without invasion (n = 35). The maternal serum native thiol, total thiol, disulfide, and IMA levels of the groups were evaluated.ResultsThe native thiol, total thiol, and IMA values were significantly lower in the case group than in the control group (p < 0.001). The disulfide values were similar between the study and control groups (p = 0.488). When the AIP and placenta previa without invasion groups were compared, the levels of native thiol, total thiol, disulfide, and IMA were similar (p > 0.05).ConclusionsMaternal serum thiol and IMA levels were lower in placenta previa cases compared to the control group. However, these parameters were not useful in predicting AIP cases.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 86%

Evaluation of maternal serum thiol and ischemia‐modified albumin levels in cases of placenta previa: A case–control study in a tertiary center

Denizli,

Tanacan,

Bastemur

et al. 2024

J of Obstet and Gynaecol

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“…Clinical research has shown that levels of free thiols in maternal serum are decreased in pregnancies with IUGR and preeclampsia, indicating decreased antioxidant capacity. However, values overlapped between the groups, limiting their diagnostic applicability [ 57 , 58 , 59 ]. Ischemia modified albumin (IMA) has especially been studied in relation to preeclampsia [ 60 ].…”

Section: Approaches To Increase Diagnostic Accuracy and Identify Neon...mentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

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Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile. There is a need to differentiate between IUGR and SGA whenever possible, as IUGR in particular is associated with greater perinatal morbidity, prematurity and mortality, as well as an increased risk for diseases in later life. Recognizing fetuses and newborns being “at risk” in order to monitor them accordingly and deliver them in good time, as well as to provide adequate follow up care to ameliorate adverse sequelae is still challenging. This review article discusses approaches to differentiate IUGR from SGA and further increase diagnostic accuracy. Since adverse prenatal influences increase but individually optimized further child development decreases the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood. Moreover, we present current concepts of pathophysiology, with a focus on oxidative stress and consecutive inflammatory and metabolic changes as key molecular mechanisms of adverse sequelae, and look at future scientific opportunities and challenges. Most importantly, awareness needs to be raised that pre- and postnatal care of IUGR neonates should be regarded as a continuum.

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“…Free thiol groups are part of the innate antioxidant capacity, scavenging ROS [46]. Clinical research has shown that levels of free thiols in maternal serum are decreased in pregnancies with IUGR and preeclampsia [47][48][49]. Ischemia modified albumin (IMA) has especially been studied in relation to preeclampsia [50].…”

Section: Maternal and Neonatal Serum Biomarkersmentioning

confidence: 99%

Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels

Nüsken,

Appel,

Saschin

et al. 2023

Preprint

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Intrauterine growth restriction (IUGR) and being born small for gestational age (SGA) are two distinct conditions with different implications for child development. IUGR is associated with greater perinatal morbidity and mortality and can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnios, lack of growth in the interval, estimated weight <3rd percentile). IUGR may also be present in neonates with birth weights above the 10th percentile. Recognizing fetuses being “at risk” of a higher perinatal mortality and morbidity rate in order to monitor them accordingly and deliver them in good time is still challenging. This review article summarizes approaches to increase the diagnostic accuracy of IUGR and presents current concepts of pathophysiology with a focus on oxidative stress and consecutive inflammatory and metabolic changes. Since prenatal influences affect the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood and look at future scientific challenges. It should be emphasized that prenatal and postnatal care of IUGR neonates should be regarded as a continuum.

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Dynamic Thiol/Disulfide Homeostasis in Predicting Adverse Neonatal Outcomes in Fetal Growth Restriction

Cited by 7 publications

References 26 publications

Evaluation of maternal serum thiol and ischemia‐modified albumin levels in cases of placenta previa: A case–control study in a tertiary center

Evaluation of maternal serum thiol and ischemia‐modified albumin levels in cases of placenta previa: A case–control study in a tertiary center

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels

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