We present a simple model for estimating the probability of interplanetary panspermia in the recently discovered system of seven planets orbiting the ultracool dwarf star TRAPPIST-1 and find that panspermia is potentially orders of magnitude more likely to occur in the TRAPPIST-1 system compared with the Earth-to-Mars case. As a consequence, we argue that the probability of abiogenesis is enhanced on the TRAPPIST-1 planets compared with the solar system. By adopting models from theoretical ecology, we show that the number of species transferred and the number of lifebearing planets are also likely to be higher because of the increased rates of immigration. We propose observational metrics for evaluating whether life was initiated by panspermia on multiple planets in the TRAPPIST-1 system. These results are also applicable to habitable exoplanets and exomoons in other planetary systems.exoplanets | panspermia | origin of life | astrobiology T he field of exoplanetary research has witnessed remarkable advances in the past two decades, with the total number of discovered exoplanets now numbering in the thousands (1). This progress has been accompanied by a better understanding of the factors that make a planet habitable (i.e., capable of supporting life) (2). It is now well-known that there exist ∼ 10 10 habitable planets in the Milky Way, many of which orbit M dwarfs (3). Planets in the habitable zone (HZ)-the region theoretically capable of supporting liquid water-of M dwarfs have been extensively studied, because they are comparatively easier to detect and analyze (4).The search for exoplanets around nearby low-mass stars has witnessed two remarkable advances over the past year, namely (i) the discovery of Proxima Centauri b, the nearest exoplanet to the solar system (5), and (ii) the discovery of seven planets transiting the ultracool dwarf star TRAPPIST-1 (6). The latter is all of the more remarkable, because three of seven planets reside within the HZ; also, each of them has a mass and a radius that are nearly equal to those of the Earth (7). Hence, the TRAPPIST-1 transiting system represents a unique opportunity for carrying out additional observations to determine whether these planets possess atmospheres and perhaps, even biosignatures (8).If conditions favorable for the origin of life (abiogenesis) exist on one of the TRAPPIST-1 planets, this possibility raises an immediate question with profound consequences: could life spread from one planet to another (panspermia) through the transfer of rocky material? Panspermia has been widely investigated in our own solar system as a potential mechanism for transporting life to or from the Earth (9-13). The planets in the HZ of the TRAPPIST-1 system are separated only by ∼ 0.01 a.u., tens of times less than the distance between Earth and Mars. Thus, one would be inclined to hypothesize that panspermia would be enhanced in this system.Here, we explore this possibility by proposing a simple quantitative model for panspermia within the TRAPPIST-1 system. We show that ...