2024
DOI: 10.1161/circulationaha.123.064301
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Dynamics of Endothelial Cell Generation and Turnover in Arteries During Homeostasis and Diseases

Yi Li,
Zixin Liu,
Ximeng Han
et al.

Abstract: BACKGROUND: Endothelial cell (EC) generation and turnover by self-proliferation contributes to vascular repair and regeneration. The ability to accurately measure the dynamics of EC generation would advance our understanding of cellular mechanisms of vascular homeostasis and diseases. However, it is currently challenging to evaluate the dynamics of EC generation in large vessels such as arteries because of their infrequent proliferation. METHODS: By usi… Show more

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Cited by 10 publications
(1 citation statement)
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“…The VEGF family and their receptor VEGFR1-R3 are extensively studied pathways in vasculature development, playing crucial roles in both developmental and pathological angiogenesis [34]. VEGFR2 is a major mediator of the physiological and pathological effects of VEGFs, which mediates EC proliferation and migration, sprouting angiogenesis through different downstream signaling [35,36].…”
Section: Discussionmentioning
confidence: 99%
“…The VEGF family and their receptor VEGFR1-R3 are extensively studied pathways in vasculature development, playing crucial roles in both developmental and pathological angiogenesis [34]. VEGFR2 is a major mediator of the physiological and pathological effects of VEGFs, which mediates EC proliferation and migration, sprouting angiogenesis through different downstream signaling [35,36].…”
Section: Discussionmentioning
confidence: 99%