Dynamics of hematologic parameters and of the erythrocyte deformability index at the juvenal period of rats and guinea pigs

Novozhilov, A. V.; Katyukhin, L. N.; Feizullaev, B. A.

doi:10.1134/s0022093012010057

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The elastic modulus of RBC membrane was measured in WKY and SHR over a 20-week period, i.e., from 3 to 23 weeks of age, while fluctuations in RBC membrane rigidity were found in both rat strains [32]. Our data are more similar to those obtained by a study focused on the period from birth to 3 months of age in Wistar rats, where an increase in RBC deformability index was observed up to 4 weeks of age, while its decrease was observed later [33]. To the best of our knowledge, the changes in NO production by RBCs between the young juvenile and young adult individuals were not documented yet.…”

Section: Rbc Deformability and No Production By Rbcs-focus On Age-rel...supporting

confidence: 85%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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Erythrocyte deformability, crucial for oxygen delivery to tissues, plays an important role in the etiology of various diseases. As the factor maintaining the erythrocyte deformability, nitric oxide (NO) has been identified. Reduced NO bioavailability also plays a role in the pathogenesis of hypertension. Our aim was to determine whether aging and hypertension affect erythrocyte deformability and NO production by erythrocytes in experimental animals divided into six groups according to age (7, 20 and 52 weeks), labeled WKY-7, WKY-20 and WKY-52 for normotensive Wistar-Kyoto (WKY) rats, and SHR-7, SHR-20 and SHR-52 for spontaneously hypertensive rats (SHR). The filtration method for the determination of erythrocyte deformability and the fluorescent probe DAF-2 DA for NO production were applied. Deformability and NO production by erythrocytes increased at a younger age, while a decrease in both parameters was observed at an older age. Strain-related differences in deformability were observed at 7 and 52 weeks of age. SHR-7 had reduced deformability and SHR-52 had increased deformability compared with age-matched WKY. Changes in NO production under hypertensive conditions are an unlikely primary factor affecting erythrocyte deformability, whereas age-related changes in deformability are at least partially associated with changes in NO production. However, an interpretation of data obtained in erythrocyte parameters observed in SHRs of human hypertension requires precaution.

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Section: Rbc Deformability and No Production By Rbcs-focus On Age-rel...supporting

confidence: 85%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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“…The main tendency of this restructuring is a gradual increase in the concentration of erythrocytes against the background of a decrease in their size, volume, and hemoglobin content, which contributes to an increase in the efficiency of their participation in oxygen transport processes and significantly improves rheological properties. The number of reticulocytes sharply decreases between the first and second weeks of life, along with shifts in the proportions of cells of different degrees of maturity (the content of I and II degrees decreases with a parallel increase in the content of III and IV degrees) [1][2][3]. One of the developers of the method of ektacytometric analysis previously revealed that the membrane deformability and mechanical stability of immature reticulocytes are markedly reduced to about 10% of the norm, while in more mature reticulocytes these parameters are almost normal [4].…”

Section: Resultsmentioning

confidence: 99%

Dynamics of Deformation Properties of Erythrocytes in Wistar Rats during Postnatal Ontogeny

Katyukhin

Novozhilov

2021

Bull Exp Biol Med

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We performed a detailed analysis of changes in the profiles of osmotic deformability using the method of gradient ektacytometry. Changes in all determinants that form the deformation properties of red blood cells in Wistar rats in the juvenile period and before puberty were determined. The dynamics of the formation of the rheological properties of the blood after birth is characterized by a wave-like change in the studied determinants. The changes are explained by adaptive reactions to extrauterine life as a result of hematopoiesis activation and the transition of the red bone marrow to a new level of functioning with the predominant replacement of physiological reticulocytosis in newborns with mature erythrocytes. The most critical period is from 10 days to 1 month after birth. Starting from the second month, the deformation parameters of erythrocytes are stabilized.

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Reference database of hematological parameters for growing and aging rats

et al. 2017

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Dynamics of hematologic parameters and of the erythrocyte deformability index at the juvenal period of rats and guinea pigs

Cited by 3 publications

References 15 publications

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Dynamics of Deformation Properties of Erythrocytes in Wistar Rats during Postnatal Ontogeny

Reference database of hematological parameters for growing and aging rats

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