Dynamics of relationship between the presence of Coxiella burnetii DNA, antibodies, and intrinsic variables in cow milk and bulk tank milk from Danish dairy cattle

Angen, Øystein; Ståhl, Marie; Agerholm, Jørgen Steen; Christoffersen, Anna-Bodil; Agger, Jens Frederik

doi:10.3168/jds.2011-4197

Cited by 26 publications

(10 citation statements)

References 12 publications

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“…In a multilevel analysis of data from the same study, but with cow as the analytical unit, we also found that the hygienic precautions reduced the risk of antibody positivity [5]. The similarity in results between cow and herd level analysis corresponds with our estimation of correlation between BTM antibody level and the within herd seroprevalence (R 2 = 0.36; P < 0.001) in a previous study [6] of a subsample of 12 of the same herds as in the present study. However, Taurel et al .…”

Section: Resultssupporting

confidence: 78%

Risk factors for Coxiella burnetii antibodies in bulk tank milk from Danish dairy herds

et al. 2013

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The aim was to identify risk factors associated with Coxiella burnetii antibody positivity in bulk tank milk (BTM) samples from 100 randomly selected Danish dairy cattle herds. Antibody levels were measured by an enzyme-linked immuno-sorbent assay. Before testing the herds, the farm managers were interviewed about hired labour, biosecurity, housing and herd health during the 12 months prior to the study. Variables considered important for C. burnetii antibody positivity in multivariable logistic regression analysis included the sharing of machines between farms (OR = 3.6), human contacts (OR = 4.2), artificial insemination by other people than artificial insemination technicians (OR = 7.7), routine herd health contract with the veterinarian (OR = 4.3) and hygiene precautions taken by veterinarians (OR = 5). In addition, herd size, hired labour, trading of cattle between farms, quarantine and use of calving and disease pens also showed significant association in univariable analysis. This study demonstrates that strict biosecurity is important for the prevention of infections with C. burnetii.

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Section: Resultssupporting

confidence: 78%

Risk factors for Coxiella burnetii antibodies in bulk tank milk from Danish dairy herds

et al. 2013

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“…DNA from placenta and bone marrow samples was extracted by using the DNeasy Blood and Tissue Kit (QIAGEN, Hilden, Germany) according to the manufacturer’s instructions. DNA from the cream layer of fresh breast milk samples was extracted by using a previously described protocol that included washing with phosphate-buffered saline and subsequent extraction with the DNeasy Blood and Tissue Kit ( 20 ). PCR was conducted with primers targeting the multicopy gene IS 1111 as described ( 21 ).…”

Section: Methodsmentioning

confidence: 99%

Adverse Pregnancy Outcomes andCoxiella burnetiiAntibodies in Pregnant Women, Denmark

Nielsen¹,

Mølbak²,

Henriksen³

et al. 2014

Emerg. Infect. Dis.

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“…This study included analyses assessing perinatal calf mortality both before and after the estimated level of BTM antibodies. The rationale behind looking forward was that high levels of antibodies has been associated with high levels of C. burnetii in milk at least 6 months prior to occurrence of antibodies [9]. Thus, the effect of C. burnetii on perinatal mortality would be expected to have occurred in the past.…”

Section: Methodsmentioning

confidence: 99%

Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves

Nielsen

Agger

et al. 2011

Acta Vet Scand

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BackgroundCoxiella burnetii is a well-known cause of placentitis and subsequent abortion in ruminants, but there are no reports on the relationship with perinatal mortality. The study was performed to determine the influence of level and change of bulk tank milk (BTM) antibodies to C. burnetii on two outcomes associated with parturition in cattle: a) stillbirth; and b) stillbirth and neonatal mortality combined (perinatal death).MethodsTwenty-four Danish dairy herds were tested repeatedly for antibodies to C. burnetii in BTM using a commercial ELISA. Samples were collected monthly from July 2008 to July 2009. Information on the 2,362 calvings occurring in the study period was obtained from the Danish Cattle Database. Two multilevel logistic regression models were created for the two outcomes stillbirth and perinatal mortality. One model included the level of BTM antibodies in a specified period before or after the outcome had occurred. The other model included the change in antibodies over time. These predictors were included both at herd and animal level. Furthermore, all models included parity and breed.ResultsThe individual monthly BTM antibody levels were highly correlated within herds. Consequently, changes in BTM antibody levels were not found to be associated with neither risk of stillbirth nor the risk of perinatal mortality. However, the risk of stillborn calves and perinatal death was higher with high level of BTM antibodies 8 to 9 months after the incident, but not outside this period.ConclusionWe conclude that the level of antibodies to C. burnetii in BTM may be associated with perinatal mortality, but the association was not persistent and should be investigated further.

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Dynamics of relationship between the presence of Coxiella burnetii DNA, antibodies, and intrinsic variables in cow milk and bulk tank milk from Danish dairy cattle

Cited by 26 publications

References 12 publications

Risk factors for Coxiella burnetii antibodies in bulk tank milk from Danish dairy herds

Risk factors for Coxiella burnetii antibodies in bulk tank milk from Danish dairy herds

Adverse Pregnancy Outcomes andCoxiella burnetiiAntibodies in Pregnant Women, Denmark

Association between antibodies to Coxiella burnetii in bulk tank milk and perinatal mortality of Danish dairy calves

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