Dynamins combine mechano-constriction and membrane remodeling to enable two-step mitochondrial fission via a ‘snap-through’ instability
Haleh Alimohamadi,
Elizabeth Wei-Chia Luo,
Rena Yang
et al.
Abstract:Mitochondrial fission is controlled by dynamin proteins, the dysregulation of which is correlated with diverse diseases. Fission dynamins are GTP hydrolysis-driven mechanoenzymes that self-oligomerize into helical structures that constrict membrane to achieve fission, but details are not well understood. However, dynamins can also remodel membranes by inducing negative Gaussian curvature, the type of curvature required for completion of fission. Here, we examine how these drastically different mechanisms syner… Show more
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