Dysbaric Osteonecrosis

Sharareh, Behnam; Schwarzkopf, Ran

doi:10.1097/jsm.0000000000000093

Cited by 28 publications

(12 citation statements)

References 37 publications

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“…Additionally, fat cell hypertrophy, fat embolization, intravascular coagulation [1], and osteocyte apoptosis [22] have been suggested as important hypotheses for pathogenetic mechanism of ONFH. Several studies have investigated the association between ONFH and specific diseases to understand the pathogenesis of non-traumatic ONFH, in which bone cell death from compromised microvascular circulation is believed the result of trauma, corticosteroid, alcohol use, blood dyscrasias as well as other conditions such as Gaucher disease, Caisson disease, HIV, SLE, radiation treatment, pregnancy, inflammatory bowel disease, gout, smoking, and even malignant tumors [23][24][25][26][27][28][29][30][31][32]. Regarding the association with solid tumor, ONFH has been recognized as a…”

Section: Discussionmentioning

confidence: 99%

Risk factors for osteonecrosis of the femoral head in brain tumor patients receiving corticosteroid after surgery

et al. 2020

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Non-traumatic osteonecrosis of the femoral head (ONFH) is a plausible complication in brain tumor patients. Frequent use of corticosteroid therapy, chemotherapy, and oxidative stress for managing brain tumors may be associated with the development of ONFH. However, there is little knowledge on the prevalence and risk factors of ONFH from brain tumor. This study aimed to investigate the prevalence and risk factors of ONFH in patients with primary brain tumors. Methods This retrospective cohort study included data from consecutive patients between December 2005 and August 2016 from a tertiary university hospital in South Korea. A total of 73 cases of ONFH were identified among 10,674 primary brain tumor patients. After excluding subjects (25 out of 73) with missing data, history of alcohol consumption or smoking, history of femoral bone trauma or surgery, comorbidities such as systemic lupus erythematosus (SLE), sickle cell disease, cancer patients other than brain tumor, and previous diagnosis of contralateral ONFH, we performed a 1:2 propensity score-matched, case-control study (ONFH group, 48; control group, 96). Risk factors of ONFH in primary brain tumor were evaluated by univariate and multivariate logistic regression analyses. Results The prevalence of ONFH in patients with surgical resection of primary brain tumor was 683.9 per 100,000 persons (73 of 10,674). In this cohort, 55 of 74 patients (74.3%) underwent THA for ONFH treatment. We found that diabetes was an independent factor associated with an increased risk of ONFH in primary brain tumor patients (OR = 7.201, 95% CI, 1.349-38.453, p = 0.021). There was a significant difference in univariate analysis, including

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Section: Discussionmentioning

confidence: 99%

Risk factors for osteonecrosis of the femoral head in brain tumor patients receiving corticosteroid after surgery

et al. 2020

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“…Among extrinsic or iatrogenic causes are decompression sickness, 1 , 4 alcohol consumption 1 , 2 and chronic use of corticosteroids 1 2 …”

Section: Discussionmentioning

confidence: 99%

“…Multifocal involvement has a prevalence of only 3% 3 . Prominent among occupational causes is dysbaric disease 4 . Occupational exposure to aluminum is a rare cause of disease, 5 and its relationship with pneumoconiosis has been established 5 …”

Section: Introductionmentioning

confidence: 99%

Multifocal osteonecrosis secondary to occupational exposure to aluminum

et al. 2017

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Multifocal osteonecrosis is a rare disease; chronic use of corticosteroids is considered the main risk factor. Patients with chronic renal failure can develop aluminum toxicity, which can lead to osteomalacia and encephalopathy. An association between osteonecrosis and aluminum toxicity has been reported among patients with dialytic renal insufficiency. Occupational exposure to aluminum rarely causes lung disease and no cases of bone lesions resulting from exposure to this metal have been reported. In this manuscript, we describe a novel case of a patient with multifocal osteonecrosis associated with chronic occupational exposure to aluminum. Level of Evidence IV, Case Report.

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“…Outras patologias menos comuns, 14 15 16 17 18 19 como doença de Gaucher, doença de Caisson, disbarismo por mergulhos em águas profundas, assim como HIV, radioterapia, gravidez, tabagismo e gota também podem levar a ONCF. Um estudo recente demonstrou que, em casos idiopáticos, alterações acetabulares com menor cobertura da cabeça femoral podem estar relacionadas à ONCF.…”

Section: Introductionunclassified

Osteonecrose da cabeça femoral: Artigo de atualização

Miyahara

Ranzoni

Ejnisman

et al. 2022

Rev Bras Ortop (Sao Paulo)

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ResumoEntre as patologias que acometem a articulação coxofemoral, a osteonecrose da cabeça femoral (ONCF) é provavelmente a mais intrigante e desafiadora. Consiste em uma doença multifatorial, com um espectro muito variável em sua apresentação clínica. Tem efeito devastador, devido a quadros dolorosos incapacitantes tanto para atividades habituais quanto esportivas. Dada a gama enorme de fatores de risco, tais como uso prolongado de corticoides (principalmente em casos de doenças reumatológicas), sequelas de trauma, anemia falciforme, HIV, etilismo, tabagismo, discrasias sanguíneas, e várias outras doenças que comprometem a irrigação sanguínea da cabeça femoral, a ONCF tem apresentação clínica e prognósticos bem variados, o que dificulta a determinação de um tratamento específico, especialmente em casos nos quais ainda não houve acometimento condral e a articulação do quadril ainda se mantém preservada, sendo estes os principais fatores encontrados na literatura que determinam as classificações desta patologia. No leque de tratamentos, encontramos diversas opções para os casos em que se tenta salvar a articulação: tratamento conservador, descompressão simples e/ou associada a algum tipo de tratamento adjuvante (enxertia homóloga, enxertia sintética, enxertos vascularizados, parafusos de tântalo, e injeção de aspirado de medula óssea), e, para casos nos quais já há fratura subcondral e/ou colapso da cabeça femoral e/ou diminuição do espaço articular, reserva-se, comumente, a realização de osteotomias femorais ou artroplastia total do quadril.

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Dysbaric Osteonecrosis

Abstract: Although the incidence of DON has decreased significantly over the past 2 decades, the lack of timely diagnosis and optimal management keeps DON relevant in the orthopedic and sport medicine community.

Cited by 28 publications

References 37 publications

Risk factors for osteonecrosis of the femoral head in brain tumor patients receiving corticosteroid after surgery

Risk factors for osteonecrosis of the femoral head in brain tumor patients receiving corticosteroid after surgery

Multifocal osteonecrosis secondary to occupational exposure to aluminum

Osteonecrose da cabeça femoral: Artigo de atualização

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