Dysfunction in superior frontal gyrus associated with diphasic dyskinesia in Parkinson’s disease

Abstract

Alterations in brain function in Parkinson’s disease (PD) patients with diphasic dyskinesia have not been investigated. We aimed to explore the alterations in regional brain function. Each of 53 levodopa (LD)-treated PD patients had two resting-state functional magnetic resonance imaging (rs-fMRI) scans in the same morning, before and after taking LD. The regional homogeneity (ReHo) approach was used to reveal local synchronization changes. Two-way factorial repeated measures analysis of covariance, with group as a between-subject factor and LD effect as a within-subject factor, was performed to explore the two main effects and interaction. Interactive analysis was used to show outcomes that combined disease status and LD effect. Spearman’s correlations were used to detect associations between interactive brain regions and severity of dyskinetic symptoms, assessed by the Unified Dyskinesia Rating Scale (UDyRS) scores, along with moderation analyses. There was no significant difference in the main group effect analysis. Significantly different clusters obtained from main LD effect analysis were in left caudate nucleus and putamen. ReHo values decreased in the caudate nucleus and increased in the putamen during the ON state after taking LD. Interaction between group and LD effect was found in left medial superior frontal gyrus (mSFG), where there were the lowest ReHo values, and was negatively correlated with UDyRS scores in the diphasic dyskinetic group during the ON state. The relationship was independent of LD dose. Abnormal local synchronization in the mSFG is closely associated with the development of diphasic dyskinesia in PD patients.

Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea

“…Based on the results of Li et al (2013) and Shen et al (2020) , the SFG, a connecting node between the central executive network and default mode network (DMN), is linked to the cognitive control network and the cognitive executive network. The MFG, a location where the ventral and dorsal attention networks converge, is involved in language fluency, object naming and directed attention and is part of the cognitive executive network ( Japee et al, 2015 ; Viñas-Guasch and Wu, 2017 ).…”

White matter connectivity networks predict levodopa-induced dyskinesia in Parkinson’s disease

“…In line with our results, previous imaging studies showed a possible relationship between dyskinesias and SFG. An fMRI study reported that an abnormal local synchronization in the left SFG is closely associated with the development of diphasic dyskinesia in patients with PD [38]. Patients with schizophrenia, with tardive dyskinesia, showed a reduced SFG volume, which correlated with the severity of their dyskinesia [25].…”

Regulatory Effects of Acupuncture on Emotional Disorders in Patients With Menstrual Migraine Without Aura: A Resting-State fMRI Study

“…ReHo is based on a data-driven approach and thus requires no prior knowledge and has good test-retest reliability ( Zuo et al, 2013 ). ALFF and ReHo analysis has been used to study migraine in our previous study ( Liu et al, 2015 ), and other diseases like premenstrual syndrome ( Pang et al, 2020 ), Alzheimer’s disease ( Li et al, 2020a ), and Parkinson’s disease ( Shen et al, 2020 ), among others.…”