Dyslipidemia after allogeneic hematopoietic stem cell transplantation: evaluation and management

Griffith, Michelle L.; Savani, Bipin N.; Boord, Jeffrey B.

doi:10.1182/blood-2010-03-276576

Cited by 71 publications

(55 citation statements)

References 53 publications

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“…30 Dyslipidemia occurs in 45%-80% of solid-organ transplantation patients on immunosuppressive agents, and hypertension and insulin resistance are well-reported side effects of corticosteroids and calcineurin inhibitors. 30,31 Furthermore, withdrawal of these medications may not necessarily result in resolution of CVRFs. 10,32 In the current study, the majority of allogeneic HCT patients were on immunosuppressive therapy at the time of CVRF diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease

Armenian

Sun

Vase

et al. 2012

Blood

188

187

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Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease

Armenian

Sun

Vase

et al. 2012

Blood

188

187

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“…Statins are effective for controlling the hypercholesterolemia and hypertriglyceridemia of patients who have received an allogeneic hematopoietic stem cell transplant [13][14][15][16][17] or solid organ transplant [18,19]. However, statins are pleiotropic compounds provided with anti-inflammatory, immunomodulatory, and antithrombotic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Hypercholesterolemia and hypertriglyceridemia develop in 40%-70% of patients after transplantation of solid organs or hematopoietic stem cells [13][14][15] and contribute to the high frequency of cardiovascular disease in transplant patients [16,17].…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after Transplantation: Case Report after Allogeneic Hematopoietic Transplantation and Review of Literature

Milone¹

2017

JSRT

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“…Bu yüzden KHN hastalarında omega-3 tüketiminin toplam yağ tüketiminin %20'sini oluşturması önerilmektedir. 24 TPN'de yağ asitleri kullanımının amacı KHN sonrasında metabolizmada oluşan oksidatif strese karşı korumadır. Lipitsolüsyonlarının temel bileşeni olan w-6 yağ asidinden zengin olan bitkisel yağlardır.…”

Section: Beslenme Desteği̇: Li̇pi̇t Solüsyonlariunclassified

Hematopoietic Stem Cell Transplantation and Current Nutritional Approaches: Review

Metin¹,

Dere²

2017

Turkiye Klinikleri J Pediatr

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ök hücre nakli (KHN); kemik iliği hasar görmüş hastalarda kemik iliği fonksiyonunun yeniden yapılandırılması amacıyla intravenöz (IV) ya da oral yüksek doz kemoterapi veya radyoterapiyi takiben Hematopoetik Kök Hücre Nakli ve Güncel Beslenme Yaklaşımları Ö ÖZ ZE ET T Hematopoetik kök hücre nakli (KHN); lösemilerin, solid tümörlerin, bazı hematolojik, nö-rolojik, metabolik ve otoimmün hastalıkların tedavisinde kullanılmaktadır. Hastanın kendi kök hücrelerinin kendisine verilmesiyle (otolog kök hücre nakli) veya başka bir vericiden hastaya kök hücre transfer edilmesiyle (allojeneik kök hücre nakli) yapılabilmektedir. KHN sonrası, donörden alınan kök hücrelerle birlikte verilen sağlıklı T-lenfositlerin aracılık ettiği, şiddetli immünolojik reaksiyon sonucu görülen organ disfonksiyonu ile karakterize, ortaya çıkış zamanına göre akut veya kronik seyreden graft-versus-host-hastalığı (GVHH) gelişebilmekte ve bu durum en önemli mortalite ve morbidite sebebi olarak kabul edilmektedir. Hastalarda KHN sonrası görülen komplikasyonları (kusma, diyare, oral mukozit, anoreksiya) azaltmak, iyileşme sürecini hızlandırmak, hematopoezi desteklemek, doku reddini ve GVHH'ı önlemek için beslenme durumunun saptanması ve beslenme desteğinin sağlanması gerekmektedir. Bu amaçla oral alımın sağlanamadığı ya da yetersiz sağlanabildiği durumlarda enteral, total parenteral ya da kombine beslenme seçenekleri değerlendirilmeli, hastanın enerji, protein, lipit, karbonhidrat, vitamin ve mineral gereksinimleri sağlanmalıdır. Son dönemde bu hasta grubunda yapılan çalışmalarda, omega-3 yağ asitleri, glutamin, D vitamini ve prebiyotik/probiyotiklerin olumlu etkileri bildirilmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Hematopoetik kök hücre transplantasyonu; beslenme tedavisi; enteral beslenme; parenteral beslenme; graft vs host hastalığı A AB BS ST TR RA AC CT T Hematopoietic stem cell transplantation (HSCT) which is used in the treatment of solid tumors, some hematologic, neurologic, metabolic and autoimmune diseases can be operated autologous (involving tissues or cells that are genetically similar) or allogeneic (involving tissues or cells that are genetically dissimilar). Healthy T-lymphocyte-mediated acute or chronic graft-versus-host-disease (GVHD) according to stem cells taken from a donor can result in severe immunological reaction characterized by organ dysfunction may be seen after HSCT. This complication is considered as the most important cause of morbidity and mortality. Determining nutritional status and improving by nutritional support is essential in order to reduce complications (vomiting, diarrhea, oral mucositis, anorexia), accelerate the healing process, prevent rejection, support emerging hematopoiesis and prevent GVHD. For this purpose, total parenteral or enteral nutrition or combined options should be considered when oral feeding is not enough. The patient's energy, protein, lipid, carbohydrate, vitamin and mineral requirements must be provided. Recent studies reported favourable effects of omega-3 fatty aci...

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Dyslipidemia after allogeneic hematopoietic stem cell transplantation: evaluation and management

Cited by 71 publications

References 53 publications

Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease

Cardiovascular risk factors in hematopoietic cell transplantation survivors: role in development of subsequent cardiovascular disease

Rhabdomyolysis after Transplantation: Case Report after Allogeneic Hematopoietic Transplantation and Review of Literature

Hematopoietic Stem Cell Transplantation and Current Nutritional Approaches: Review

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