Dysmorphogenesis in psychosis: Quantitative and qualitative measures involving the head and face

McGrath, John J.; Grim, V.; Cardy, Sue; Chapple, Ben; Mowry, Bryan

doi:10.1016/s0920-9964(00)90498-5

Cited by 3 publications

(12 citation statements)

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“…Morphological integration enjoys good support from various studies in literature which associate developmental dysmorphogenesis of skull (and consequently of brain) with genesis of certain neuropsychiatric disorders, which include various craniofacial anomalies (ending in neurocognitive dysfunction) (8), syndromes featuring mental retardation (7,21), and distinct psychiatric diseases (17,18). Associated studies assert that it may be one of the etiomechanisms involved in causation of such diseases (8,17,18).…”

Section: Literary Evidences Linking Etiogenesis Of Neuropsychiatric Dmentioning

confidence: 97%

“…Plausibly, these variations accumulated in the long course of evolution (33)(34)(35), through assimilation of co-variances (34,35) and epigenetic changes (36) in the gross and genetic structure of a population respectively, implied morphological integration (34,37). The inclusion of variations in the skull components in the course of evolution might have subjected a population to acquire and propagate multiple errors at molecular level (3) and to express these as aberrant genotypes and phenotypes (38), setting basis for etiogenesis of certain neuropsychiatric disorders (10,12,18,7).…”

Section: Evolutionary Aspectmentioning

confidence: 99%

“…Genetic integration has been confirmed in the human skulls (3), and the evidences indicate that a particular skull dysmorphogenesis may be a phenotypic expression of such a faulty genetic integration (3,16)which may manifest as neurocognitive dysfunction (17,18).…”

Section: Genetic Aspectmentioning

confidence: 99%

“…An ontogenetic evolutionarily linking integration, of phenotypic variations across generations in hominid skulls, has also been marked in literature (13,15). The narratives derived from available studies suggest that accumulating effects of erroneous craniocerebral development, which have been registered in the genomic structure of a population following the evolutionary trail, may emerge as a neuropsychiatric disorder (3,(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Morphological integration in human skull and its possible role in etiogenesis of neuropsychiatric disorders: Deciphering the link between evolution, development and disease

A.¹

2017

Preprint

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Structure-function interdependence is a universal phenomenon in biological systems. Any alteration in structural features may result in change in functions-leading to natural selection of a particular trait, or dysfunctions thereof. Many such alterations arise during the course of evolution of a species and may meticulously be traced during embryonic development of an organism. Through, the theoretical construct of morphological integration, a set of phenotypic traits alter in a coordinated and integrated manner during evolution and embryonic development of an organism yielding efficient and environmentally adapted physiological functions pertinent to those structures. Such integration may go awry sometimes, setting the basis for genesis of diseases.Morphological integration in human skull has been established through various methods. The brain-skull co-development is handcuffed through evolution and development, and the very basis of a neuropsychiatric disorder could be underlying in dysmorphogenesis of the skull, its consequent effect on structures, and thus functions of the pertinent brain components. Here we propose that morphological integration in human skull may be mechanistically implied in etiogenesis of certain neuropsychiatric disorders and should be borne in mind during clinical diagnosis and therapeutic interventions.

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Section: Literary Evidences Linking Etiogenesis Of Neuropsychiatric Dmentioning

confidence: 97%

Section: Evolutionary Aspectmentioning

confidence: 99%

Section: Genetic Aspectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Morphological integration in human skull and its possible role in etiogenesis of neuropsychiatric disorders: Deciphering the link between evolution, development and disease

A.¹

2017

Preprint

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“…Cultured dermal 69 fibroblasts have been demonstrated to be a convenient 70 and useful model for investigating schizophrenia 71 (Mahadik and Mukherjee, 1996 (McGrath et al, 2000). Subjects 89 were assessed with the Diagnostic Interview for 90 Psychosis (Jablensky et al, 1999) …”

mentioning

confidence: 99%

Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines

Catts

McGrath

et al. 2006

Schizophrenia Research

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Abstract16 Introduction: The aim of this study was to investigate whether there is an increased susceptibility to apoptosis in cultured 17 fibroblasts from patients with schizophrenia. 18 Method: Dermal fibroblasts were collected and cultured from three groups: patients with schizophrenia, patients with non-19 schizophrenic psychosis, and healthy comparison subjects. Susceptibility to apoptosis was measured at the level of degradation 20 product (proportion of cells in the sub-G0 cell cycle fraction in which apoptotic bodies accumulate), pro-apoptotic effector 21 (activated caspase-3), and molecular regulators (P53, Bax and Bcl-2). Cell lines were studied under both basal culture and 22 cycloheximide (an apoptotic inducer) exposure conditions. 23 Results: Consistent with increased susceptibility to apoptosis, the proportion of sub-G0 cells under basal conditions was 24 significantly larger in the schizophrenia group, compared to the non-schizophrenic psychosis group. However when apoptosis 25 was stimulated with cycloheximide, the schizophrenia group showed an attenuated caspase-3 response. The pattern of 26 correlations between regulators, caspase-3 and the proportion of sub-G0 cells was different in the schizophrenia group, 27 consistent with group-specific apoptotic pathway dysregulation.0920-9964/$ -see front matter D

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Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease

Kumar¹,

Pandey²,

Faiq³

et al. 2020

Preprint

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Structure - function interdependence is a universal phenomenon in biological systems. Any alteration in structural features may result in change in functions–leading to natural selection of a particular trait, or dysfunctions thereof. Many such alterations arise during the course of evolution of a species and may meticulously be traced during embryonic development of an organism. Through the theoretical construct of morphological integration, a set of phenotypic traits alter in a coordinated and integrated manner during evolution and embryonic development of an organism yielding efficient environmentally adapted physiological functions pertinent to those structures. Such integration may go awry sometimes, setting the basis for genesis of diseases. Morphological integration in human skull has been established through various methods. The brain-skull co-development is handcuffed through evolution and development, and the very basis of a neuro-psychiatric disorder could be underlying in dysmorphogenesis of the skull, its consequent effect on structures, and thus functions of the pertinent brain components. Here we propose that morphological integration in human skull may be mechanistically implied in etiogenesis of certain neuro-psychiatric disorders and should be borne in mind during clinical diagnosis and therapeutic interventions.

show abstract

Dysmorphogenesis in psychosis: Quantitative and qualitative measures involving the head and face

Cited by 3 publications

References 0 publications

Morphological integration in human skull and its possible role in etiogenesis of neuropsychiatric disorders: Deciphering the link between evolution, development and disease

Morphological integration in human skull and its possible role in etiogenesis of neuropsychiatric disorders: Deciphering the link between evolution, development and disease

Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines

Morphological Integration in Human Skull and Its Possible Role in Etiogenesis of Neuropsychiatric Disorders: Deciphering the Link between Evolution, Development and Disease

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