Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target

Jafarzadeh, Abdollah; Paknahad, Mohammad Hossein; Nemati, Maryam; Jafarzadeh, Sara; Mahjoubin‐Tehran, Maryam; Rajabi, Ali; Shojaie, Layla; Mirzaei, Hamed

doi:10.1016/j.biopha.2021.112600

Cited by 25 publications

(14 citation statements)

References 141 publications

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“…Sponging miR-625-5p in turn is likely to drive cervical cancer progression, and this has been demonstrated recently 36 . Jafarzadeh et al suggested that miR-330-3p promoted pro-tumorigenic events in various cancers like lung cancer, pancreatic cancer, bladder cancer and cervical cancer, and that its downregulation could stall tumor development 37 , both observations consistent with its oncomir identity disclosed here. Further, miR-95-3p has been implicated in activating the wnt/βcatenin pathway in prostate cancer tissues 38 , thereby promoting cell proliferation, migration and invasion, consistent with its oncomir identity disclosed here.…”

Section: Discussionsupporting

confidence: 88%

CESCProg: A COMPACT PROGNOSTIC MODEL AND NOMOGRAM FOR CERVICAL CANCER BASED ON miRNA BIOMARKERS

Muthamilselvan

Palaniappan

2023

Preprint

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Cervical squamous cell carcinoma, more commonly cervical cancer, is the fourth common cancer among women worldwide with substantial burden of disease, and less-invasive, reliable and effective methods for its prognosis are necessary today. Micro-RNAs are increasingly recognized as viable alternative biomarkers for direct diagnosis and prognosis of disease conditions, including various cancers. In this work, we addressed the problem of systematically developing an miRNA-based nomogram for the reliable prognosis of cervical cancer. Towards this, we preprocessed public-domain miRNA -omics data from cervical cancer patients, and applied a cascade of filters in the following sequence: (i) differential expression criteria with respect to controls; (ii) significance with univariate survival analysis; (iii) passage through dimensionality reduction algorithms; and (iv) stepwise backward selection with multivariate Cox modeling. This workflow yielded a compact prognostic DEmiR signature of three miRNAs, namely hsa-miR-625-5p, hs-miR-95-3p, and hsa-miR-330-3p, which were used to construct a risk-score model for the classification of cervical cancer patients into high-risk and low-risk groups. The risk-score model was subjected to blind validation on an unseen test dataset, yielding a one-year AUROC of 0.84 and five-year AUROC of 0.71. The model was validated with an out-of-domain, external dataset yielding significantly worse prognosis for high-risk patients. The risk-score was combined with significant features of the clinical profile to establish a validated predictive prognostic nomogram. Both the miRNA-based risk score model and the integrated nomogram are freely available for academic and not-for-profit use at CESCProg, a web-app (https://apalania.shinyapps.io/cescprog).

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Section: Discussionsupporting

confidence: 88%

CESCProg: A COMPACT PROGNOSTIC MODEL AND NOMOGRAM FOR CERVICAL CANCER BASED ON miRNA BIOMARKERS

Muthamilselvan

Palaniappan

2023

Preprint

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“…The miRNAs can negatively modulate genes’ expressions by binding their 3′-UTRs, which act as crucial effectors in the malignant behaviors of tumor cells [ 6 ]. MiR-330-3p is located on chromosome 19q12.32 [ 7 ] and is bound to the malignant behaviors of cancerous cells; It plays a moderator role in different cancers [ 8 ]. Long non-coding RNAs (lncRNAs) are a type of RNA transcript with a length longer than 200 nucleotides without protein-coding ability [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

NONHSAT021545/miR-330-3p/EREG: A Cooperative Axis in Breast Cancer Prognosis and Treatment

Zhang

Guo

Yang

et al. 2023

JCM

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Lymphatic metastasis is the most common form in breast cancer (BC) progression. Previously, we observed that lnc045874, a most conservative homology of Homo Sapiens NONHSAT021545 (lnc021545), miR-330-3p, and EREG may have some effects in mouse hepatocarcinoma cell lines with different lymphatic metastasis potentials. Through data from TCGA and GEO database analysis, we speculated that miR-330-3p might be a tumor promoter, while EREG could be a tumor suppressor in BC. MiR-330-3p was upregulated, while lnc021545 and EREG were downregulated in 50 BC tissues. MiR-330-3p advanced the metastatic behaviors of BC cells, whereas lnc021545 and EREG resulted in the opposite effects. The three molecules’ expressions were correlated respectively and showed that miR-330-3p targeted lnc021545 and EREG to affect their expressions. Lnc021545/miR-330-3p axis affected BC metastasis by regulating EREG in epithelial-to-mesenchymal transition. In 50 BC patients, these three molecules and their cooperation are associated with aggressive tumor phenotypes, patient outcomes, and trastuzumab therapy. We finally discovered that lnc021545, miR-330-3p, and EREG formed a multi-gene co-regulation system that affected the metastasis of BC and the cooperation reflects the synergistic effects of the three molecules, recommending that their cooperation may provide a more accurate index for anti-metastasis therapeutic and prognostic evaluation of BC.

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“…binding to mRNAs and thereby promoting degradation of the target mRNA or blocking its translation into protein (19,(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78)(79).…”

Section: N2bmentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target

Cited by 25 publications

References 141 publications

CESCProg: A COMPACT PROGNOSTIC MODEL AND NOMOGRAM FOR CERVICAL CANCER BASED ON miRNA BIOMARKERS

CESCProg: A COMPACT PROGNOSTIC MODEL AND NOMOGRAM FOR CERVICAL CANCER BASED ON miRNA BIOMARKERS

NONHSAT021545/miR-330-3p/EREG: A Cooperative Axis in Breast Cancer Prognosis and Treatment

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

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