2023
DOI: 10.1101/2023.12.04.570014
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Dysregulated Repeat Element Viral-like Immune Response in Hepatocellular Carcinoma

Avril K. Coley,
Chenyue Lu,
Amaya Pankaj
et al.

Abstract: PurposeDysregulation of viral-like repeat RNAs are a common feature across many malignancies that are linked with immunological response, but the characterization of these in hepatocellular carcinoma (HCC) is understudied. In this study, we performed RNAin situhybridization (RNA-ISH) of different repeat RNAs, immunohistochemistry (IHC) for immune cell subpopulations, and spatial transcriptomics to understand the relationship of HCC repeat expression, immune response, and clinical outcomes.Experimental DesignRN… Show more

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