E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor

Differential expression of E‐cadherin and catenins in ovarian sex cord stromal tumours

“…17 In contrast, Ohishi et al, using an antibody for which the immunogen is human E-cadherin Cterminal recombinant protein, showed frequent nuclear expression in the majority of the neoplasms studied, including 90% of adult GCTs, 67% of Sertoli cell tumours and 64% of fibrothecomas, whereas all serous carcinomas showed no nuclear localization. 18,19 This is in agreement with our results, where using the same antibody as Ohishi et al we found nuclear localization of E-cadherin in all SCSTs studied. We had investigated previously the expression of E-cadherin in the same set of MCST included in this study, using a different E-cadherin antibody, and all tumours showed no nuclear expression.…”

“…Stewart et al ., using an antibody generated using E‐cadherin and glutathione S‐transferase (GST) recombinant protein, showed membranous localization of E‐cadherin in GCTs, but no nuclear localization was observed in any cases studied . In contrast, Ohishi et al ., using an antibody for which the immunogen is human E‐cadherin C‐terminal recombinant protein, showed frequent nuclear expression in the majority of the neoplasms studied, including 90% of adult GCTs, 67% of Sertoli cell tumours and 64% of fibrothecomas, whereas all serous carcinomas showed no nuclear localization . This is in agreement with our results, where using the same antibody as Ohishi et al .…”

β‐Catenin and E‐cadherin expression in stage I adult‐type granulosa cell tumour of the ovary: correlation with tumour morphology and clinical outcome

“…In contrast, antibodies directed against the membranous domain of E‐cadherin, such as that used in the current study, show only membranous or cytoplasmic labelling 29 . The significance of nuclear E‐cadherin expression in normal and neoplastic granulosa cells has yet to be determined, although there may be a diagnostic role in the evaluation of ovarian neoplasms 30 …”

The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders

“…58 However, 10% of endocervical adenocarcinomas, 94 40% of breast adenocarcinoma, 95 and 66% of esophageal adenocarcinomas are HLA-G positive. 96 Similarly, inhibin-a is expressed in 20% of melanomas, 94,97 20% of endocervical adenocarcinomas, 94 22% of large cell lung carcinomas, 98 and 10% of high-grade ovarian serous carcinomas, 99 in addition to most ovarian gonadal stromal tumors. Inhibin-a is expressed in only 40% of exaggerated placental site reaction and intermediate trophoblastic tumors.…”

“…Other markers, such as nuclear E-cadherin, demonstrated positivity in 90% of granulosa cell tumors and in none of the cases with carcinoid or adenocarcinoma. 99 Granulosa Cell Tumor Versus Low-Grade Endometrial Stromal Sarcoma.-CD10, inhibin, CD99, and calretinin.…”