E-cigarette use behaviors and device characteristics of daily
exclusive e-cigarette users in Maryland: Implications for
product toxicity

Aherrera, Angela; Aravindakshan, Atul; Jarmul, Stephanie; Olmedo, Pablo; Chen, Rui; Cohen, Joanna E.; Navas‐Acien, Ana; Rule, Ana M.

doi:10.18332/tid/128319

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…All the measured iAs concentrations in this study exceed the CalEPA REL; however, this REL represents continuous exposure, in contrast to the intermittent nature of vaping. The FDA sets permissible daily exposure (PDE) limits for elemental impurities in inhalation medications, in units of µg/day, which can be converted to concentration units of µg/g by dividing by daily dose in grams [28] . MOD e-liquid consumption has been reported at 32.5 mL median weekly [29] or 5 mL/day [30] ; assuming a density of 1.14 ± 0.06 (mean ± SD) g/mL [Supplementary Table 5], 5 mL of e-liquid is approximately equivalent to 5.7 g consumed per day.…”

Section: Resultsmentioning

confidence: 99%

Arsenic and arsenic species in MOD, POD, and disposable POD electronic cigarette aerosols: a pilot study

Tehrani¹,

Ahererra²,

Tanda³

et al. 2023

J Environ Expo Assess

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The growing popularity of electronic cigarettes (e-cig) has raised questions about the health effects of e-cig use, or vaping. Previous studies have reported on the potential of exposure to arsenic (As) and other metal(loid)s from vaping, but little is known about the speciation of As in the inhaled aerosols, an important determinant of toxicity. Inorganic As (iAs) species AsIII and AsV are generally more hazardous than organic As species. This study aimed to investigate total and speciated As in condensed aerosols of popular commercial e-cig products and to compare them with regulatory exposure limits. High-performance liquid chromatography and inductively-coupled plasma mass spectrometry were used for As measurements of e-cig aerosol condensates. The analysis included samples from three types of e-cig devices: MODs, PODs, and disposable pod (d-POD) devices. iAs species were identified in all 23 analyzed e-cig aerosol condensate samples, with the highest aerosol concentrations measured in MODs. The geometric mean (range) iAs concentration of 2.3 (1.2-5.1) µg/m3 observed in MOD devices in this study exceeded the recommended exposure limit of 2 µg/m3 for 15-min or shorter inhalation exposures set by the United States National Institute for Occupational Safety and Health. These preliminary results suggest that iAs species are present in inhalable aerosols of some MOD products at levels above regulatory limits for iAs inhalation.

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Section: Resultsmentioning

confidence: 99%

Arsenic and arsenic species in MOD, POD, and disposable POD electronic cigarette aerosols: a pilot study

Tehrani¹,

Ahererra²,

Tanda³

et al. 2023

J Environ Expo Assess

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show abstract

“…This finding has been observed in other studies. 31 , 32 Aherrera et al 33 observed in a cohort study of 150 participants that exclusive ENDS use was associated with more wheezing than nonuse. However, after adjusting for sex, age, and former smoking status, this association was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Electronic Nicotine Delivery Systems With Cigarette Use and Self-reported Wheezing in the US Adult Population

et al. 2023

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ImportanceThe prevalence of electronic nicotine delivery systems (ENDS) use has increased, leading to a concern about their respiratory health outcomes. It is unclear whether ENDS use increases the risk of wheezing, a common symptom of respiratory conditions.ObjectiveTo provide an analysis of the longitudinal association between ENDS and cigarette use and self-reported wheezing among US adults.Design, Setting, and ParticipantsThe US nationally representative Population Assessment of Tobacco and Health (PATH) Study was used. Longitudinal data for adults 18 years or older from wave 1 (2013-2014) to wave 5 (2018-2019) were analyzed. Data were analyzed from August 2021 to January 2023.Main Outcomes and MeasuresThe prevalence of self-reported wheezing (waves 2-5) was estimated for 6 strata of tobacco product use (never cigarette and noncurrent ENDS use, never cigarette and current ENDS use, current cigarette and noncurrent ENDS use, current cigarette and current ENDS use, former cigarette and noncurrent ENDS use, and former cigarette and current ENDS use). A generalized estimating equations framework evaluated the association between cigarette and ENDS use and self-reported wheezing at the subsequent wave. An interaction term between cigarette and ENDS use was added to estimate the association between joint cigarette and ENDS use categories and the association of ENDS within strata of cigarette use.ResultsThe analytical sample consisted of 17 075 US adults with a mean (SD) age of 45.4 (17) years, of whom 8922 (51%) were female and 10 242 (66%) were Non-Hispanic White. When compared with never cigarette and noncurrent ENDS use, the greatest association in reporting wheezing was for current cigarette and current ENDS use (adjusted odds ratio [AOR], 3.26; 95% CI, 2.82-3.77), which was similar to current cigarette and noncurrent ENDS use (AOR, 3.20; 95% CI, 2.91-3.51) and substantially greater than former cigarette and current ENDS use (AOR, 1.94; 95% CI, 1.57-2.41). Associations were small and not statistically significant for the odds of self-reported wheezing among never cigarette and current ENDS use when compared with never cigarette and noncurrent ENDS use (AOR, 1.20; 95% CI, 0.83-1.72), and for odds of wheezing and current cigarette and current ENDS use when compared with current cigarette and noncurrent ENDS use (AOR, 1.02; 95% CI, 0.91-1.15).Conclusions and RelevanceIn this cohort study, exclusive ENDS use was not associated with an increase in the risk of self-reported wheezing. However, a small increase in risk between ENDS use and wheezing was reported by individuals who use cigarettes. This study adds to the literature about the potential health effects associated with ENDS use.

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“…68 Assuming a typical respiratory rate of 6 L min −1 , these numbers are translated into exposure limits of 44.4 mg and 140 mg formaldehyde for 1 h and 8 h, respectively. [69][70][71] The exposure to each mL of EJ level is 64% of the 1-hour exposure limit and 20% of the 8-hour exposure limit. We note that this calculated exposure amount is only due to unheated EJ, while intensive vaping or other environmental sources can also contribute to the total exposure.…”

Section: Carbonyl Accumulation In Pure Glycolsmentioning

confidence: 99%

Autoxidation of glycols used in inhalable daily products: implications for the use of artificial fogs and e-cigarettes

Guo,

Chan,

Gautam

et al. 2023

Environ. Sci.: Processes Impacts

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E-cigarette use behaviors and device characteristics of daily exclusive e-cigarette users in Maryland: Implications for product toxicity

Cited by 20 publications

References 28 publications

Arsenic and arsenic species in MOD, POD, and disposable POD electronic cigarette aerosols: a pilot study

Arsenic and arsenic species in MOD, POD, and disposable POD electronic cigarette aerosols: a pilot study

Assessment of Electronic Nicotine Delivery Systems With Cigarette Use and Self-reported Wheezing in the US Adult Population

Autoxidation of glycols used in inhalable daily products: implications for the use of artificial fogs and e-cigarettes

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