“…(Baş & Boyacı, ). RSM has been applied for many studies successfully to describe the behavior (growth or inactivation) of microorganisms for example; spores of Bacillus sporothermodurans inactivation by nisin (Aouadhi, Rouissi, Mejri, & Maaroufi, ), Escherichia coli inactivation by visible light irradiation (Feilizadeh, Mul, & Vossoughi, ), Staphylococcus aureus , Enterococcus faecalis , Bacillus subtilis , Escherichia coli inactivation by supercritical carbon dioxide (Hossain et al, ), thermal inactivation of Alicyclobacillus acidoterrestris spores (Silva, Gibbs, Vieira, & Silva, ), Vibrio parahaemolyticus inactivation by acidic electrolyzed water (Wang et al, ).…”