E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

Abstract

ObjectiveEpidemiological studies have shown that E-selectin gene polymorphisms (A561C and C1839T) may be associated with essential hypertension (EH), but the results are conflicting in different ethnic populations. Thus, we performed this meta-analysis to investigate a more authentic association between E-selectin gene polymorphisms and the risk of EH.MethodsWe searched the relevant studies for the present meta-analysis from the following electronic databases: PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of the association between E-selectin gene polymorphisms and EH susceptibility. The pooled ORs were performed for dominant model, allelic model and recessive model. The publication bias was examined by Begg’s funnel plots and Egger’s test.ResultsA total of eleven studies met the inclusion criteria. All studies came from Asians. Ten studies (12 cohorts) evaluated the A561C polymorphism and EH risk, including 2,813 cases and 2,817 controls. The pooled OR was 2.280 (95%CI: 1.893–2.748, P<0.001) in dominant model, 5.284 (95%CI: 2.679–10.420, P<0.001) in recessive model and 2.359 (95%CI: 1.981–2.808, P = 0.001) in allelic model. Four studies (six cohorts) evaluated C1839T polymorphism and EH risk, including 1,700 cases and 1,681 controls. The pooled OR was 0.785 (95%CI: 0.627–0.983, P = 0.035) in dominant model, 1.250 (95%CI: 0.336–4.652, P = 0.739) in recessive model and 0.805 (95%CI: 0.649–0.999, P = 0.049) in allelic model.ConclusionThe current meta-analysis concludes that the C allele of E-selectin A561C gene polymorphism might increase the EH risk in Asian population, whereas the T allele of E-selectin C1839T gene polymorphism might decrease the EH risk.

E‐selectin gene in essential hypertension: a case‐control study

“…Similar results were also reported by Wang et al investigating the relationship between E‐selectin gene polymorphism and essential hypertension in Han, Kazakh and Uygur population . In a meta‐analysis conducted by Cai et al in Asian populations, the T allele of the above‐mentioned gene polymorphism is not a susceptibility factor for the disease . However, the minor allele frequency (C allele) reported in Mexican population was greater than 5% which allows detecting the variant and making reliable group comparisons .…”

“…31 In a meta-analysis conducted by Cai et al in Asian populations, the T allele of the above-mentioned gene polymorphism is not a susceptibility factor for the disease. 24 However, the minor allele frequency (C allele) reported in Mexican population was greater than 5% which allows detecting the variant and making reliable group comparisons. 36 Together, this data support the importance of E-selectin in hypertension and further investigation of genetic variability among Asian Indian populations.…”

“…Sample size (250 patients and 250 controls) is adequate for this study determined using standard statistical method in case‐control group, at the significance level of 0.05 at power 80% on the basis of prevalence of minor alleles referred from previous studies . All the patients and controls were recruited for a period of 3 years (2013‐2016) for the study.…”

“…Sample size (250 patients and 250 controls) is adequate for this study determined using standard statistical method in case-control group, at the significance level of 0.05 at power 80% on the basis of prevalence of minor alleles referred from previous studies. 20,24 All the patients and controls were recruited for a period of 3 years (2013-2016) for the study. Patients were identified and randomly selected from outpatient department clinics of hypertension and had a scheduled appointment with the cardiologist who provided their usual source of primary care at Department of Cardiology, All India Institute of Medical Sciences, New Delhi.…”

Associations of pregnancy-associated plasma protein-A level with essential hypertension and hypertensive disorders in pregnancy in Chinese population: a meta-analysis of 20 research studies involving 3332 individuals

“… 1 In general, the aetiology and the development of EH are affected by genetic as well as environmental factors. 2 3 Recently, numerous studies have shown that EH is closely related to inflammation, and inflammation plays an important role in the pathogenesis and maintenance of EH. 4 …”