EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2

Abstract

These guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The aim of the guidelines is to assist nuclear medicine practitioners when making recommendations, performing, interpreting, and reporting the results of clinical dopamine transporter (DAT) single photon emission computed tomography (SPECT) studies using (123)I-labelled radiopharmaceuticals. The aim is to achieve a high-quality standard of DAT SPECT imaging, which will increase the diagnostic impact of this technique in neurological practice. The present document is an update of the 2002 guidelines [1] and has been guided by the views of various national societies: the Task Group Neuro-Nuclear-Medicine of the German Society of Nuclear Medicine [2], a consensus statement of the imaging centres included in the "Kompetenznetz-Parkinson" sponsored by the German Federal Ministry of Education, and the Task Group of Neuro-Nuclear-Medicine of the French Society of Nuclear Medicine [3]. The guidelines reflect the individual experience of experts in European countries. The guidelines are intended to present information specifically adapted to European practice. The information provided should be taken in the context of local conditions and regulations.

A role for accelerometry in the differential diagnosis of tremor syndromes

“…In accordance with European Association of Nuclear Medicine (EANM) procedural guidelines (Darcourt et al, 2010), intravenous injection of 123I-FP-CIT (DaTscan, 185 MBq; GE Healthcare, Chicago, IL, USA) was performed 30 min after thyroid blockade (oral potassium perchlorate, 400 mg). SPECT was then performed, using a dual-head gamma camera system (E.CAM; Siemens Medical Solutions, Malvern, PA, USA) equipped with high-resolution, low-energy, parallel-hole collimators.…”

“…SPECT was then performed, using a dual-head gamma camera system (E.CAM; Siemens Medical Solutions, Malvern, PA, USA) equipped with high-resolution, low-energy, parallel-hole collimators. Standard parameters were utilized for data acquisition and reconstruction (Darcourt et al, 2010), reorienting transaxial, sagittal and coronal slices in the fronto-occipital plane. Two experienced nuclear medicine physicians interpreted the resulting views as normal or abnormal by combining qualitative assessment with semi-quantitative BasGan v2 freeware-assisted evaluation (Calvini et al, 2007).…”

Appropriate use criteria for amyloid PET imaging cannot replace guidelines: On behalf of the European Association of Nuclear Medicine

“…The length of the list of criteria of appropriate use is, however, relatively modest, in comparison to similar lists of potential indications published in guidelines on imaging of the dopaminergic system, cerebral perfusion or [ 18 F]FDG PET that we published on behalf of the European Association of Nuclear Medicine Neuroimaging (EANM) [26][27][28][29]. However, one should be aware of the fact that the published AIT appropriateness criteria are not a guideline.…”

“…Nuclear medicine guidelines follow a standardized format which include AUC, but also address technical procedures, how to read images optimally, reporting of images, safety aspects, etc. [26][27][28][29]31]. Both the SNMMI and the EANM agreed that the review process of guidelines should also be standardized [31].…”

Validation of an automated morphological MRI-based 123I-FP-CIT SPECT evaluation method

“…imaging with 123 I-FP-CIT radio-ligand is a useful diagnostic tool for the differentiation of PS from ET [1].…”