Ear Abnormalities Among Children with Fetal Alcohol Spectrum Disorder: A Systematic Review and Meta-Analysis

Cheung, Melissa Mei Yin; Tsang, Tracey W; Watkins, Rochelle; Birman, Catherine S.; Popova, Svetlana; Elliott, Elizabeth J

doi:10.1016/j.jpeds.2021.11.016

Cited by 8 publications

(2 citation statements)

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“…Comorbid conditions with the highest pooled prevalence (50-91%) included abnormal functional studies of the peripheral nervous system and special senses, conduct disorder, receptive and expressive language disorders, and chronic serous otitis media 13 . Other studies report a high prevalence of vision and hearing problems among people with FASD 265,266 . All of these comorbid conditions affect the function and QOL of individuals with FASD and their families (Box 1).…”

Section: Quality Of Lifementioning

confidence: 92%

Fetal alcohol spectrum disorders

Popova

Charness

Burd

et al. 2023

Nat Rev Dis Primers

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Alcohol readily crosses the placenta and may disrupt fetal development. Harm from prenatal alcohol exposure (PAE) is determined by the dose, pattern, timing and duration of exposure, fetal and maternal genetics, maternal nutrition, concurrent substance use, and epigenetic responses. A safe dose of alcohol use during pregnancy has not been established. PAE can cause fetal alcohol spectrum disorders (FASD), which are characterized by neurodevelopmental impairment with or without facial dysmorphology, congenital anomalies and poor growth. FASD are a leading preventable cause of birth defects and developmental disability. The prevalence of FASD in 76 countries is >1% and is high in individuals living in out-of-home care or engaged in justice and mental health systems. The social and economic effects of FASD are profound, but the diagnosis is often missed or delayed and receives little public recognition. Future research should be informed Nature Reviews Disease Primers | (2023) 9:11 2 0123456789();: PrimerFASD occur in all socioeconomic and ethnic groups 15 and are complex, chronic conditions that affect health and family functioning 16 . Individuals with FASD usually require lifelong health care as well as social and vocational support. Some require remedial education and others interact with the justice system. Early diagnosis and a strength-based management approach will optimize health outcomes.FASD are the most common of the potentially preventable conditions associated with birth anomalies and neurodevelopmental problems 13 , and their global effects, including huge social and economic costs, are substantial 17 . For example, in Canada, the annual cost associated with FASD is an estimated ~CAD$ 1.8 billion (CAD$ 1.3 billion to CAD$ 2.3 billion) 17 , which is attributable in part to productivity loss (41%), correction services (29%) and health care (10%). In North America, the lifetime cost of supporting an individual with FASD is estimated at >CAD$ 1 million 18 . Addressing and preventing alcohol use in pregnancy is a public-health imperative.This Primer presents the epidemiology of FASD and the latest understanding of its pathophysiology as well as approaches to diagnosis, screening and prevention. The Primer also describes outcomes across the lifespan, management and quality of life (QOL) of people living with FASD, and highlights important areas for future research and clinical practice. Epidemiology Alcohol use during pregnancyNo safe level of PAE has been established 19 , and international guidelines advise against any amount or type of alcohol use during pregnancy [20][21][22][23] . Nevertheless, ~10% of pregnant women worldwide consume alcohol 24,25 . The highest prevalence of alcohol use during pregnancy is in the WHO European Region (25.2% 24 ; Fig. 1), consistent with the prevalence of heavy alcohol use, heavy episodic drinking and alcohol use disorders in this region 26 . 0123456789();: PrimerIn 40% of the 162 countries evaluated, >25% of women who consumed any alcohol during pregnancy drank at 'bing...

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Section: Quality Of Lifementioning

confidence: 92%

Fetal alcohol spectrum disorders

Popova

Charness

Burd

et al. 2023

Nat Rev Dis Primers

Self Cite

120

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“…Ophthalmic complications (Gummel & Ygge, 2013;Reid et al, 2021;Tsang et al, 2022), structural and functional ear complications were associated with FASD (Cheung et al, 2022;Popova et al, 2016), increased infection risk, asthma and skin conditions (Reid et al, 2019(Reid et al, , 2021 were all commonly reported in children with FASD/PAE. First Nations peoples in Canada with FASD (aged 20-42 years) reported complex physical needs such as respiratory diseases, cardiovascular complications, gastrointestinal issues, chronic pain, and dental issues (Flannigan, McMorris, et al, 2022).…”

Section: Physical Health (N = 21 Studies)mentioning

confidence: 99%

Factors to be considered as part of a holistic assessment for fetal alcohol spectrum disorder: A scoping review

Reid,

Kent,

Hewlett

et al. 2023

Alcohol: Clinical and Experimental Research

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BackgroundA scoping review was undertaken to identify factors outside of current fetal alcohol spectrum disorder (FASD) diagnostic criteria that could be considered as part of a holistic assessment process to enable targeted recommendations and supports to improve outcomes. Evidence will be used to inform the revision of the Australian Guide to the Diagnosis of FASD.MethodsSix electronic databases were searched. Studies were eligible if they included factors outside of the diagnostic criteria that clinicians might need to consider as part of a holistic (i.e., physical, social, mental health and wellbeing) assessment process. Data charting and content analysis was performed for synthesis of results.Results121 studies were included that spanned 12 key areas. This included physical health, sleep, adverse postnatal experiences, substance use/other risk‐taking behaviors, contact with the criminal justice system, mental health, First Nations cultural considerations, transition to adult roles, involvement with the out‐of‐home care system, feeding and eating, strengths/interests/external resources and incontinence.ConclusionsAreas to be considered as part of a holistic assessment and diagnostic process spanned individual, family, and system level factors. The results of the current review provide guidance for clinicians regarding the wide range of factors that may influence long‐term health, development, and wellbeing for individuals with prenatal alcohol exposure and FASD. In practice this guidance can be used to inform an individualized assessment process to facilitate tailored recommendations and supports to best meet the complex needs of those living with FASD and their families.

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Fetal Alcohol Spectrum Disorder in Australia: From Fiction to Fact and to the Future

Elliott

Bower

2022

Fetal Alcohol Spectrum Disorder

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Ear Abnormalities Among Children with Fetal Alcohol Spectrum Disorder: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 65 publications

Fetal alcohol spectrum disorders

Fetal alcohol spectrum disorders

Factors to be considered as part of a holistic assessment for fetal alcohol spectrum disorder: A scoping review

Fetal Alcohol Spectrum Disorder in Australia: From Fiction to Fact and to the Future

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