Early Administration of Hyperbaric Oxygen Therapy in Distraction Osteogenesis - A Quantitative Study in New Zealand Rabbits

Wang, I-Chun; Ueng, Steve Wen–Neng; Yuan, Li-Jen; Tu, Yuan‐Kun; Lin, Song–Shu; Wang, Chao-Ran; Tai, Ching‐Lung; Wang, Kun-Chang

doi:10.1097/01.ta.0000169872.38849.b0

Cited by 23 publications

(16 citation statements)

References 14 publications

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“…The bone segments from HBO-treated animals had higher mineral densities and superior biomechanical properties compared with the control animals. Using the same experimental model, this group obtained similar findings, showing that HBO is also advantageous during the early stages of tibial fracture healing (21). …”

Section: Discussionmentioning

confidence: 65%

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Neves¹,

Abib²,

Neves³

et al. 2013

Clinics

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OBJECTIVES:The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures.METHODS:A total of 128 male New Zealand albino rabbits, between 6–8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each): control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red.RESULTS:Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group.CONCLUSION:Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model.

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Section: Discussionmentioning

confidence: 65%

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Neves¹,

Abib²,

Neves³

et al. 2013

Clinics

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“…[2,50] Deneysel çalışmalarda HBO tedavisinin potansiyel yararlar sağladığına ilişkin bulgulara rağmen, insanlardaki kemik kırıklarının iyileşmesi, gecikmiş kırık iyileşmesi veya kaynamamaya ilişkin tedavideki olumlu etkisi tam olarak gösterilememiştir. [50,51] Kemik kırığı, kaynama gecikmesi veya kaynamama durumları için HBO tedavisinin kullanımını destekleyen veya reddeden yeterli sayıda randomize kontrollü çalışma bulunmamaktadır. [2] Uygulanan HBO tedavi yöntemi; 1,5-3 ATA'da, %100 oksijenin, 30-60 dakika süresince uygulanması şeklindedir.…”

Section: Kırık İyileşmesiunclassified

Hiperbarik oksijen tedavisi

Ozan¹,

Altay²,

Kayalı³

2017

TOTBID

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“…Wang and colleagues, in a rabbit model, were able to demonstrate that distraction segments of animals treated with HBO had increased bone mineral density and superior mechanical properties comparing to the controls and yields better results when applied during the early stage of the tibial healing process [Wang et al 2005].…”

Section: Fracturesmentioning

confidence: 99%

Hyperbaric Oxygen Effects on Sports Injuries

Barata¹,

Cervaens

Resende

et al. 2011

Therapeutic Advances in Musculoskeletal

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In the last decade, competitive sports have taken on a whole new meaning, where intensity has increased together with the incidence of injuries to the athletes. Therefore, there is a strong need to develop better and faster treatments that allow the injured athlete to return to competition faster than with the normal course of rehabilitation, with a low risk of re-injury. Hyperbaric therapies are methods used to treat diseases or injuries using pressures higher than local atmospheric pressure inside a hyperbaric chamber. Within hyperbaric therapies, hyperbaric oxygen therapy (HBO) is the administration of pure oxygen (100%) at pressures greater than atmospheric pressure, i.e. more than 1 atmosphere absolute (ATA), for therapeutic reasons. The application of HBO for the treatment of sports injuries has recently been suggested in the scientific literature as a modality of therapy either as a primary or an adjunct treatment. Although results have proven to be promising in terms of using HBO as a treatment modality in sports-related injuries, these studies have been limited due to the small sample size, lack of blinding and randomization problems. HBO seems to be promising in the recovery of injuries for high-performance athletes; however, there is a need for larger samples, randomized, controlled, double-blinded clinical trials combined with studies using animal models so that its effects and mechanisms can be identified to confirm that it is a safe and effective therapy for the treatment of sports injuries.

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Early Administration of Hyperbaric Oxygen Therapy in Distraction Osteogenesis - A Quantitative Study in New Zealand Rabbits

Cited by 23 publications

References 14 publications

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Hiperbarik oksijen tedavisi

Hyperbaric Oxygen Effects on Sports Injuries

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