“…DMA was performed according to five outcomes, that is, POUR (39 studies, n = 4,697), PVRU (five studies, n = 490), UTI (four studies, n = 326), LUTS (three studies, n = 437) and AE (19 studies, n = 1949). For POUR, 39 studies were included with 4/6 pairs of interventions 17 , 18 , 20 , 21 , 23 , 26 , 28 , 30 – 32 , 35 – 56 , 60 – 63 which were significant in the incidence of POUR relative to PLA, that is, AMB ( n = 398), ACU ( n = 325), OPI ( n = 429) and ALP ( n = 5206) with the pooled RR [95% confidence interval (CI)] of 0.44 (0.32, 0.61), 0.32 (0.11, 0.94), 0.62 (0.40, 0.95) and 0.55 (0.40, 0.76), respectively ( Supplemental Figure 2 ). The heterogeneity was varied with the I 2 ranged from 63.54 to 73.34.…”