Early and late allergic reaction in the nose assessed by whole body plethysmography

Bruin‐Weller, Marjolein S. de; Weller, F. R.; Scholte, Arthur J.; Rijssenbeek, L. H. M.; Baan, S. Van Der; Bogaard, J. M.; Monchy, J. G. R. De

doi:10.1183/09031936.96.09081701

Cited by 11 publications

(9 citation statements)

References 17 publications

(16 reference statements)

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“…Cytology is useful for the late phase: an increase in the eosinophil count of >10% (10) indicated positive NPC results in nine of the 11 patients who had apparently tested negative according to clinical scores during the immediate phase. Nasal cytology is more sensitive than RNM or whole-body plethysmography (13) for detecting the late-phase response and is suitable for children because it is painless and ambulatory.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of nasal provocation challenge with allergens in children

Rémy¹,

Rufin²,

Pfister

et al. 1998

Allergy

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A total of 106 children suffering from perennial rhinitis and/or asthma, and all allergic to Dermatophagoides pteronyssinus (DP), underwent nasal provocation challenge (NPC) with DP to determine the best method of diagnosis. Posterior rhinomanometry was uninterpretable in 17 patients and gave negative results in 31. Clinical scores for sneezing and rhinorrhea were more effective but did not diagnose the disorder in 11 children. However, nine of the 11 had significant increases in eosinophil count in the late phase. Clinical scores and cytology were also useful for assessing whether NPC with allergens was positive in children. The feasibility and safety of NPC with DP are high for rhinitic and stable asthmatic patients, but mild reactions may occur during the late phase.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of nasal provocation challenge with allergens in children

Rémy¹,

Rufin²,

Pfister

et al. 1998

Allergy

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“…The authors recently performed a series of studies on repeated allergen challenges in the skin, nose and lower airways [ 40]. The effect of repeated allergen challenge in skin on early and especially on late allergic responses was first studied as it was speculated that repeated intradermal skin challenges might be a suitable model to study effects of repeated allergen exposure in the airways.…”

Section: Repeated Experimental Allergen Challengementioning

confidence: 99%

“…Because the authors were especially interested in late phase responses, a new, very sensitive technique was developed to record nasal reactions after allergen challenge. For this purpose a whole body plethysmography was used [ 6]. Large differences in response patterns to the repeated challenges were found in the nose and the skin, especially concerning the late response, varying from strongly enhanced responses to complete diminution of the response.…”

Section: Repeated Experimental Allergen Challengementioning

confidence: 99%

Repeated allergen challenge as a new research model for studying allergic reactions

Bruin-Weller¹,

Weller

Monchy

1999

Clin Experimental Allergy

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Repeated allergen challenge might be a more relevant model for studying symptomatic disease, because it gives more information on the patient's handling of chronic allergen exposure. Thus, this experimental model has more resemblance to the situation of natural allergen exposure, and the allergen load can be standardized. However, the response to repeated allergen challenge in individual patients can show a large variation, that is from a strongly enhanced response to complete diminution of the response. Successful allergen immunotherapy can change the response pattern of repeated allergen challenge in the skin into down-regulation of the late reaction. Chronic or repeated allergen exposure may result in an enhanced allergen-specific allergic response, involving allergen-specific T-cell activation. Different subsets of T cells can exert either activating or suppressive effects on inflammatory cells involved in subsequent allergic reactions. CD8+ T cells might exert suppressive effects, because they seem to be associated with a subsequent down-regulation of the late skin reaction after repeated allergen challenge (Fig. 4). Further studies are needed to compare the responses to repeated allergen challenge with the response to natural seasonal allergen exposure in the same patients and to explore possible underlying mechanisms using, for example, nasal biopsies.

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“…One of our objectives was to assess mucosal indices using nasal lavage techniques, which would have interfered with rhinomanometry measurements. De Bruin-Weller et al (20) described nasal LPR using whole body plethysmography , but found no correlation between the late phase data and measurements obtained using more common methods for nasal patency assessments, such as rhinomanometry and nasal peak ow. Others, however, have described a reduced nasal patency, assessed by rhinomanometry, 4 and 8 h after allergen challenge.…”

Section: Discussionmentioning

confidence: 99%

Dual Symptomatic and Exudative Nasal Responses are not Characteristics of Perennial Allergic Rhinitis

Andersson

Rimmer

Salome

et al. 2001

Acta Oto-Laryngologica

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Acute and late phase (dual) symptomatic responses after allergen challenge commonly occur in allergic asthma. The aim of the present study was to explore the occurrence of allergen challenge-induced biphasic responses in patients with chronic perennial allergic rhinitis living in an area with high house dust mite (HDM) exposure. Fifteen patients with perennial rhinitis and evident allergy to HDM participated. Nasal challenges with HDM and sham were performed on separate days in a crossover design. Nasal symptoms, forced expiratory volume in 1 s (FEV1) and orally exhaled nitric oxide were recorded every hour for up to 8 h after each challenge. Alpha2-macroglobulin and eosinophil cationic protein (ECP) were analysed in hourly nasal lavages, and nasal histamine provocations were carried out after 8 h. HDM, but not sham, caused an immediate increase in nasal symptoms which gradually abated over the 8-h period. No reoccurrence of nasal late phase symptoms was seen. HDM, but not sham, induced an early increase in alpha2-macroglobulin and ECP levels: both indices remained elevated for up to 3 h after challenge. HDM challenge evoked hyper-responsiveness to histamine expressed as increased nasal symptoms (p < 0.05; HDM vs sham). No differences in exhaled nitric oxide or FEV1 were demonstrated at any one time point between the HDM- and sham-challenged days. It is concluded that nasal symptomatic and exudative late phase responses may not be a general feature, even in subjects with perennial rhinitis challenged with high, symptom-provoking, doses of HDM allergen.

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Early and late allergic reaction in the nose assessed by whole body plethysmography

Cited by 11 publications

References 17 publications

Diagnostic value of nasal provocation challenge with allergens in children

Diagnostic value of nasal provocation challenge with allergens in children

Repeated allergen challenge as a new research model for studying allergic reactions

Dual Symptomatic and Exudative Nasal Responses are not Characteristics of Perennial Allergic Rhinitis

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