Early- and late-latency gamma auditory steady-state response in schizophrenia during closed eyes: Does hallucination status matter?

Griškova-Bulanova, Inga; Hubl, Daniela; Swam, Claudia van; Dierks, Thomas; Koenig, Thomas

doi:10.1016/j.clinph.2016.02.009

Cited by 28 publications

(14 citation statements)

References 61 publications

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“…Subsequently, these authors found that the time to peak "late-latency" γ-band amplitude (early-gamma = 0-100 ms, late-gamma = 200-300 ms), irrespective of phase-locking, distinguished AH from non-AH patients (ie, AH longer), and that longer time to peak was positively correlated with AH severity. 64 Using a similar paradigm, Hirano and colleagues 65 also found that phase-locking was significantly reduced in SCZ compared to controls at 40 Hz only, however, nonphase-locked mean γ-band power (amplitude) was not different between the groups at rest and was increased during 40 Hz ASSR stimulation in SCZ. Also in SCZ, AH symptoms were positively correlated with induced 40 Hz γ-band power in the left hemisphere and negatively correlated with the ASSR stimulation phaselocking factor.…”

Section: Phase Synchronizationmentioning

confidence: 94%

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Jardri

Hugdahl

Hughes

et al. 2016

SCHBUL

138

106

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This review from the International Consortium on Hallucinations Research intends to question the pertinence of the excitatory-to-inhibitory (E/I) imbalance hypothesis as a model for hallucinations. A large number of studies suggest that subtle impairments of the E/I balance are involved in neurological and psychiatric conditions, such as schizophrenia. Emerging evidence also points to a role of the E/I balance in maintaining stable perceptual representations, suggesting it may be a plausible model for hallucinations. In support, hallucinations have been linked to inhibitory deficits as shown with impairment of gamma-aminobutyric acid transmission, N-methyl-d-aspartate receptor plasticity, reductions in gamma-frequency oscillations, hyperactivity in sensory cortices, and cognitive inhibition deficits. However, the mechanisms by which E/I dysfunctions at the cellular level might relate to clinical symptoms and cognitive deficits remain unclear. Given recent data advances in the field of clinical neuroscience, it is now possible to conduct a synthesis of available data specifically related to hallucinations. These findings are integrated with the latest computational frameworks of hallucinations, and recommendations for future research are provided.

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Section: Phase Synchronizationmentioning

confidence: 94%

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Jardri

Hugdahl

Hughes

et al. 2016

SCHBUL

138

106

View full text Add to dashboard Cite

show abstract

“…Using simultaneous EEG-fMRI, class D microstates have been suggested to be related to a right-lateralized frontoparietal network associated with attention reorientation (Britz et al, 2010). Koenig et al used measure of phase synchrony and demonstrated a left-lateralized phase synchrony −decrease in patients with AVH during 40 Hz auditory stimulation, in contrast to a phase synchrony −increase in healthy subjects or patients without AVH (Koenig et al, 2012, Griskova-Bulanova et al, 2016). …”

Section: Eeg-based Connectivity Analysesmentioning

confidence: 99%

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Ćurčić‐Blake

Ford

Hubl

et al. 2017

Progress in Neurobiology

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181

155

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HighlightsThe language, auditory and memory/limbic networks are of particular relevance for auditory verbal hallucinations.An increased interaction among the auditory-language and striatal brain regions occurs while patients hallucinate.Fronto-temporal connections are often altered in AVH individuals, but there is no consensus regarding increase or decrease.Connections of the interhemispheric auditory pathway are stronger for first episode patients, but they are weaker in chronic patients.The majority of studies support hybrid AVH hypotheses in which all three networks and the striatal network are involved.

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“…Phase-locking index (PLI, corresponding to the phase consistency over epochs) and event-related spectral perturbation (ERSP, corresponding to the average power over epochs) measures (more details can be found in Mørup et al 2007) were calculated within 38-42 Hz and -100 -0 and 200-500 ms windows, the former resulting in a baseline measure and the latter corresponding to the latelatency gamma (Tada et al 2016). Response window from 200 ms was chosen in order to exclude the impact of onset and capture both the maximum response and the steady-state part, as previously done in (Rojas et al 2011;Griskova-Bulanova et al 2016). The wavelet-transform derived measures of the late-latency gamma response were normalized by subtracting the mean of the baseline.…”

Section: Eeg Analysismentioning

confidence: 99%

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

et al. 2017

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The 40 Hz auditory steady-state response (ASSR) is a periodic response to a periodic stimulation. Its sources are located in the primary auditory cortex and the asymmetry of the planum temporale has previously been associated with hand preference and gender-related differences; thus subject's handedness and gender could potentially influence ASSRs. Nevertheless, electrophysiological studies of ASSRs are mainly dominated by right-handed participants and the observed findings can only be generalized to the right-handed populations. However, for a potential use of 40 Hz ASSR as a translational biomarker of neuropsychiatric disorders, it is important to investigate the response in association to handedness and gender. We included an equal number of left-handed and right-handed males and females and recorded EEG responses during left-ear, right-ear and both ears stimulation. The results of the study suggest that the processing of 40 Hz auditory stimulation depends on the subjects' gender and handedness: significantly lower phase-locking and strength of 40 Hz ASSRs were observed in left-handed females as compared to left-handed males, but right-handers did not differ in 40 Hz ASSRs. Our observation of the opposite impact of gender in the examined handedness groups stresses the importance of careful consideration of handedness and gender factors when evaluating the determinants of inter individual variability of 40 Hz ASSRs. This finding is of particular importance for clinical studies in psychiatry and neurology.

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Early- and late-latency gamma auditory steady-state response in schizophrenia during closed eyes: Does hallucination status matter?

Abstract: Evaluation of auditory entrainment in both open eyes and closed eyes conditions is informative. Frequency and timing information of both early-latency and late-latency responses helps to uncover different aspects of impairment in schizophrenia patients.

Cited by 28 publications

References 61 publications

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

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