Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease

Abstract

The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS:A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). RESULTS:Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. DISCUSSION:Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.

Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach

“…In our case, a slight positivity of anti-DGP was found with a low title as the only autoantibody of CD. Anti-DGP positivity is recognized in some CD cases with a negative TTG IgA testing and normal IgA [ 77 ] and can represent an early preclinical biomarker predicting CD onset [ 78 ]. Moreover, anti-DGP have potential advantages over other conventionally used assays in milder forms of enteropathy associated with gluten-sensitive skin disorder and have been detected more frequently and at higher serum concentrations in patients with autoimmune skin disorders compared to healthy controls [ 79 ].…”

Exploring GI Diseases Across the Lifespan

“…In addition to medical care, the extremes of age also bring cost and healthcare delivery concerns, which several of our published articles focus upon (5,10,11). Finally, GI conditions unique to extremes of age need further ongoing research (12–15). We hope that this special issue will serve as a call to action to better understand the unique care of individuals in the extremes of age with GI disorders.…”

Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease

“…Different gut microbial communities between DQ2− and DQ2+ celiac patients have been found, with a prevalence of Bacteroidetes and Enterococcus and a decreased number of Clostridium perfrigens, Parabacterioidetes, and Veillonella in high-profile genetic-risk children. However, some studies have reported on the influence of the type of feeding and early antibiotic exposure on the modulation of the gut microbiota and the subsequent predisposition to develop CD [10][11][12]. Patients who underwent a gluten-free diet (which is associated with different microbiota in fecal samples) had a lower immune stimulatory effect on blood-mononuclear cells compared with patients on a regular gluten diet [1,5].…”