Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder

Fries, Gabriel R.; Vasconcelos-Moreno, Mirela Paiva; Gubert, Carolina; Santos, Bárbara Tietbohl Martins Quadros dos; Rosa, André Luiz Schuh Teixeira da; Eisele, Barbara Schneider; Sartori, Juliana; Pfaffenseller, Bianca; Kapczinski, Flávio; Kauer-Sant’Anna, Márcia

doi:10.1016/j.jad.2013.07.027

Cited by 30 publications

(23 citation statements)

References 24 publications

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“…40 In addition, cell senescence is associated with increased cellular secretion of proinflammatory cytokines 41,42 contributing to the senescence-associated secretory phenotype (SASP), which may also link telomere shortening with age-associated medical conditions, most of which are highly prevalent in patients with BD. 5 Our results add to the evidence base because we classified BD participants into early and late stages of illness, with control groups matched for age and gender.…”

Section: Discussionmentioning

confidence: 99%

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Barbé-Tuana

Parisi

Panizzutti

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age-and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.

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Section: Discussionmentioning

confidence: 99%

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Barbé-Tuana

Parisi

Panizzutti

et al. 2016

Rev. Bras. Psiquiatr.

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“…In bipolar disorders, such alterations typically emerge at an early age before or shortly after the onset of the disorder (Hasler et al, 2006). This indicates that impairments of neuroplasticity and cellular resilience, which potentially lead to neural atrophy and cell death, are important pathological processes in bipolar disorder (Fries et al, 2014;Machado-Vieira et al, 2014). In accordance with this hypothesis is the observation that white matter hyperintensities predict a good response to treatment with lithium (Kato et al, 2000).…”

Section: Structural Imagingmentioning

confidence: 84%

Toward stratified treatments for bipolar disorders

Hasler¹,

Wolf²

2015

European Neuropsychopharmacology

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“…In a recent study, a susceptibility to apoptosis in antipsychotic-naive schizophrenia patients has been found (32). Another study showed an increased apoptosis in euthymic bipolar disorder patients (33). Apoptotic neurons have been shown in some neurodegenerative disorders like Alzheimer's and Huntington's diseases (4,34,35).…”

Section: Discussionmentioning

confidence: 97%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

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Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder

Cited by 30 publications

References 24 publications

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

Toward stratified treatments for bipolar disorders

Elevated nucleosome level and oxidative stress in schizophrenia patients

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