Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three

Heuzé, Patricia; Féron, Christophe; Baudoin, Claude

doi:10.1016/s0165-3806(97)00049-7

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…Numerous test batteries exist for analyzing the development of behavioral reflexes (Fox 1965;Kodama 1993;Rogers et al 1997), sensory-motor development (Heuze et al 1997;Noel 1989;Roubertoux et al 1985Roubertoux et al , 1992, locomotor behavior (Brown et al 1999a), grooming (Bolivar et al 1996a), swimming (Bolivar et al 1996b), exploration (Tremml et al 1998), anxiety and fear (Ramboz et al 1998), ultrasonic vocalizations (Bolivar andBrown 1994;Hahn et al 1987), and social behavior (Williams and Scott 1954). Test batteries used for studying behavioral development include the Collaborative Behavioral Teratology Study Battery, the Cincinnati Psychoteratogenicity Screening Test Battery, and the Functional Observational Battery.…”

Section: Behavioral Developmentmentioning

confidence: 99%

Developing Standardized Behavioral Tests for Knockout and Mutant Mice

Brown

Stanford²,

Schellinck³

2000

ILAR Journal

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Section: Behavioral Developmentmentioning

confidence: 99%

Developing Standardized Behavioral Tests for Knockout and Mutant Mice

Brown

Stanford²,

Schellinck³

2000

ILAR Journal

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“…Body righting and negative geotaxic responses were impaired in Cacna1a rol mutants on postnatal days 14-22 and were slower on postnatal days 8-22. As mentioned above, slow body righting is a characteristic of Grid2 Lc (Thullier et al, 1997) and Rora sg (Heuzé et al, 1997) mutants. However, Grid2 Lc mutants with more severe cerebellar pathology than Cacna1a rol were faster than their wild-type controls in negative geotaxic responses (Thullier et al, 1997), indicating a reversed phenotypic expression.…”

Section: Cacna1a Rol Mutant Mousementioning

confidence: 76%

“…Rora sg mutants were compared to non‐ataxic controls from postnatal days 1 to 9 in body righting and cliff aversion tests (Heuzé et al, 1997). The body righting of Rora sg mutants was slower than that of controls on postnatal days 7–9.…”

Section: Behavioral Effects Of Neonatal Cerebellar Lesions In Rodentsmentioning

confidence: 99%

“…The overall neuropathology leads to early-onset cerebellar ataxia and deficits in motor coordination (Lalonde et al, 1996). Rora sg mutants were compared to non-ataxic controls from postnatal days 1 to 9 in body righting and cliff aversion tests (Heuzé et al, 1997). The body righting of Rora sg mutants was slower than that of controls on postnatal days 7-9.…”

Section: Rora Sg Mutant Mousementioning

confidence: 99%

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Behavioral effects of neonatal lesions on the cerebellar system

Lalonde

Strazielle

2015

Intl J of Devlp Neuroscience

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Several rodent models with spontaneous mutations causing cerebellar pathology are impaired in motor functions during the neonatal period, including Grid2(Lc), Rora(sg), Dab1(scm), Girk2(Wv), Lmx1a(dr-sst), Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats. Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8. Behavioral deficits are time-dependent following X-irradiated- or aspiration-induced lesions of the cerebellum in rats. In addition, motor functions are deficient after lesions in cerebellar-related pathways. As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions.

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“…In fact, the age at which neonatal and perinatal behavioral milestones are acquired in DS murine models can be correlated with later cognitive performance in the adult (Olmos-Serrano et al, 2016). Numerous test batteries exist for analyzing the development of behavioral reflexes (Fox, 1965;Kodama, 1993;Rogers et al, 1997), sensory-motor development (Heuze, Feron, & Baudoin, 1997;Noel, 1989), locomotor behavior (Feather-Schussler & Ferguson, 2016), grooming, exploration, and ultrasonic vocalizations (Chang, Cole, & Costa, 2017), and social behavior (Chang et al, 2017).…”

Section: Preweaning Neurodevelopmental Batterymentioning

confidence: 99%

Behavioral Phenotyping for Down Syndrome in Mice

et al. 2020

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Down syndrome (DS) is the most frequent genetic cause of intellectual disability, characterized by alterations in different behavioral symptom domains: neurodevelopment, motor behavior, and cognition. As mouse models have the potential to generate data regarding the neurological basis for the specific behavioral profile of DS, and may indicate pharmacological treatments with the potential to affect their behavioral phenotype, it is important to be able to assess disease‐relevant behavioral traits in animal models in order to provide biological plausibility to the potential findings. The field is at a juncture that requires assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this article, behavioral tests are described that are relevant to the domains affected in DS. A neurodevelopmental behavioral screen, the balance beam test, and the Multivariate Concentric Square Field test to assess multiple behavioral phenotypes and locomotion are described, discussing the ways to merge these findings to more fully understand cognitive strengths and weaknesses in this population. New directions for approaches to cognitive assessment in mice and humans are discussed. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Preweaning neurodevelopmental battery Basic Protocol 2: Balance beam Basic Protocol 3: Multivariate concentric square field test (MCSF)

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Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three

Cited by 9 publications

References 10 publications

Developing Standardized Behavioral Tests for Knockout and Mutant Mice

Developing Standardized Behavioral Tests for Knockout and Mutant Mice

Behavioral effects of neonatal lesions on the cerebellar system

Behavioral Phenotyping for Down Syndrome in Mice

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