Early Biomarkers of Renal Damage in Relation to Arterial Stiffness and Inflammation in Male Coronary Artery Disease Patients

Abstract

Background/Aims: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls. Methods: We studied 52 patients with CAD (age 63.2 ± 9.2 years) and 41 healthy controls (age 60.1 ± 7.2 years). Urinary L-FABP and KIM-1 as well as serum NGAL, adiponectin and resistin levels were measured using the enzyme-linked immunosorbent assay method. The technique of applanation tonometry was used for non-invasive pulse wave analysis and pulse wave velocity assessments. Results: Urinary L-FABP and KIM-1 were independent determinants of cf-PWV for the CAD patients (R²=0.584, P<0.001) but not for the controls. Adiponectin correlated with log-KIM-1 (r=0.31, P=0.028) only for the patients, while NGAL correlated with WBC count (rho=0.29, P=0.038; r=0.35, P=0.029) and resistin (rho=0.60, P<0.001; r=0.57, P<0.001) for both the CAD and control groups, respectively. Conclusion: Our findings suggest that urinary L-FABP and KIM-1 may be independently associated with aortic stiffness in individuals with CAD.

The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis

“…Furthermore, AS has been found to be associated with urinary creatinine excretion in chronic kidney disease [19] and renal damage has been shown to be related to AS and inflammation in patients with coronary artery disease [20]. …”

Gender Difference in the Relationship of Albuminuria and Arterial Stiffness in Chinese Adults - a 6.6-Year Follow-Up Longitudinal Study

“…aModel 1, unadjusted; Model 2, adjusted for age, BMI, diabetes mellitus, hypertension, hyperlipidemia, eGFR, smoking, alcohol drinking, physical activity status and menopausal status (in females). *p<0.05 stiffness among male coronary artery disease patients [31]. Hence, men with albuminuria should receive regular screening for arterial stiffness and even overt CVD.…”

Novel biomarkers of kidney injury and fibrosis in patients with different severity of hypertension: relation to vascular reactivity and stiffness

“…Результаты настоящего исследования также показали нарастание концентрации данного маркера с увеличением степени тяжести АГ по данным центрального аортального давления, являющегося прогностически более значимым по сравнению с периферическим, кроме того, были получены результаты взаимосвязи данного маркера со значениями системной сосудистой жесткости, что отмечалось у пациентов как с умеренной АГ так и с РАГ. Взаимосвязь уровня L-FABP в моче с показателями сосудистой жесткости была выявлена в работах некоторых зарубежных исследователей, однако в группу исследуемых были включены только пациенты с ИБС [15]. Ассоциации уровня L-FABP с изменениями показателей внутрипочечной гемодинамики у пациентов с АГ выявлено не было.…”

“…А у пациентов с РАГ также наблюдалась взаимосвязь уровня KIM-1 с показателями системной жесткости. Наличие ассоциации уровня KIM-1 в моче с показателями кфСРПВ было продемонстрировано лишь в одном исследовании Paapstel K, et al (2016) у мужчин с ИБС [15].…”