Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

Pen, Li; Cheung, Lawrence; Chiu, Brian C.-H.

doi:10.1155/2016/7056035

Cited by 3 publications

(7 citation statements)

References 9 publications

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“…In BALT, tissue biopsy demonstrates polymorphous infiltrates of small lymphocytes, plasma cells, and B cells [4]. These may form characteristic lymphoepithelial lesions; however, often times histology and immunochemistry show no definitive features of a lymphoproliferative disease, as in our patient [4,16]. Recent studies show that the presence of monoclonal immunoglobulin heavy chain (IgH) gene rearrangement using PCR may be used to confirm BALT lymphomas [4,16].…”

Section: Discussionmentioning

confidence: 84%

“…Given the possibility of synchronous lesions along the GI tract, staging for MALT lymphomas should be meticulous and include gastroscopy, colonoscopy, bone marrow biopsy and CT of thorax and abdomen [8,10,13,14]. In BALT, tissue biopsy demonstrates polymorphous infiltrates of small lymphocytes, plasma cells, and B cells [4]. These may form characteristic lymphoepithelial lesions; however, often times histology and immunochemistry show no definitive features of a lymphoproliferative disease, as in our patient [4,16].…”

Section: Discussionmentioning

confidence: 85%

“…Organisms such as Campylobacter jejuni have been implicated in MZL-MALT involving the small bowel while the Borrelia burgdorferi can cause MZL-MALT of the skin [3,8,10]. In up to 15% of cases the lung can be involved which is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma [4]. It has been postulated that approximately a quarter of patients with gastric MALT lymphoma have disseminated, multiorgan involvement at presentation.…”

Section: Discussionmentioning

confidence: 99%

“…Among these genetic abnormalities, t(11, 18) (q21;q21) is the most frequently detected translocation in H. pylorinegative gastric MALT lymphoma [1,3]. In extra gastric lymphomas, particularly pulmonary MALT/ BALT lymphomas, it occurs in up to one third of cases [4,5,8,14]. At the genomic level, this translocation causes fusion of the apoptosis inhibitor 2-gene (AP12) with the MALT1 gene which generates a fusion protein, AP12-MALT1.…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for approximately 3-7% of all B-cell lymphomas [1,3]. They originate from memory B lymphocytes normally present in the "marginal zone" of the secondary lymphoid follicle found in mucosa-associated lymphoid tissue of various organs [4,5]. This clonal B-cell neoplasm has the ability to not only recur locally, but also to transform to a more aggressive diffuse large B-cell lymphoma with potential for systemic spread [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Helicobacter Pylori-Negative Gastric- MALT Lymphoma, Disseminated to the Small bowel, Colon, and Lung

Kantor¹

2018

GMR

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Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (EMZL-MALT) have been linked to chronic immune stimulation due to infection or autoimmune stimuli. Helicobacter pylori induced gastric MALT lymphoma is the most extensively documented and well understood. However, in those where H. pylori is not detected, data is less established. Its treatment and prognosis are based on histological evaluation, immunophenotyping, and the use of fluorescence in situ hybridization (FISH), or polymerase chain reaction (PCR) to identify chromosomal translocation and/or unbalanced aberrations. The most common chromosomal translocation with pathogenic significance is t (11;18) (q21:q21). Those patients presenting with this translocation tend to have more advanced disseminated disease and are likely resistant to conventional antibiotic therapy and certain chemotherapeutic agents. Synchronous MALT lymphoma and overt distant dissemination has rarely been reported. We report a case of a 71-year-old female with biopsy confirmed H. pylori negative-gastric MALT lymphoma with disseminated disease involving the stomach, small intestine, colon, and lung. FISH analysis was positive for BIRC-3-MALT1 (11;18) fusion protein. Finally, we issue a call-to-action for much needed further data to establish clear treatment options based on clinical and diagnostic criteria, for extra-gastric, disseminated, and/or H. pylori negative MALT lymphomas. .

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Rare Case of Helicobacter Pylori-Negative Gastric- MALT Lymphoma, Disseminated to the Small bowel, Colon, and Lung

Kantor¹

2018

GMR

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Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Chung

Wilgus

Fishbein

et al. 2019

Semin Respir Crit Care Med

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Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features of SS. Primary SS is not associated with other autoimmune diseases. However, SS can complicate diverse autoimmune disorders (particularly systemic lupus erythematosus, rheumatoid arthritis, and scleroderma); this form is termed “secondary SS.” Pulmonary involvement is usually not a dominant feature of SS, but may be severe in some cases. In this review, we discuss specific tracheal, bronchiolar, and pulmonary complications of SS including xerotrachea, bronchiolitis, bronchiectasis, interstitial lung disease, nonspecific interstitial pneumonia, usual interstitial pneumonia, lymphoid interstitial pneumonia, organizing pneumonia, acute fibrinous and organizing pneumonia, pulmonary cysts, pleural effusions, pulmonary amyloidosis, and bronchus- or lung-associated lymphomas.

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Nhân một trường hợp bệnh Malt lymphoma dạ dày

Nguyen¹

2020

jcmhch

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CASE STUDY: GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (EMZL-MALT) have been linked to chronic immune stimulation due toinfection or autoimmune stimuli.The causal association between Helicobacter pylori(HP) and gastric MALT lymphoma has been well demonstrated. HPeradication with antibiotics has emerged as the standard therapy for early stage HPpositive gastric MALT lymphoma.High response rates and long-term survival have been reported inpatients with localized gastric MALT lymphomatreated with low-doseradiationtherapy.Monoclonal antibody and chemotherapy are reserved forpatients failing or recurring after RT and those with advanced stage disease. Key words: mucosa-associated lymphoid tissue, gastric lymphoma

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Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

Cited by 3 publications

References 9 publications

A Rare Case of Helicobacter Pylori-Negative Gastric- MALT Lymphoma, Disseminated to the Small bowel, Colon, and Lung

A Rare Case of Helicobacter Pylori-Negative Gastric- MALT Lymphoma, Disseminated to the Small bowel, Colon, and Lung

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Nhân một trường hợp bệnh Malt lymphoma dạ dày

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