“…In the absence of fibrosis, several phenotypic changes have been observed in a subset of clinical and preclinical studies, including the presence of vacuolar degeneration [44,60,69,85], nuclear atypia [17], necrosis [44], celljunction disruption [44,85], immune cell infiltrates [69,85] and microvascular haemorrhaging [69]. These phenotypic changes are presumed to have potential physiological consequences.…”