Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures

Salumets, Andres; Hydén-Granskog, Christel; Mäkinen, Sirpa; Suikkari, Anne‐Maria; Tiitinen, Aila; Tuuri, Timo

doi:10.1093/humrep/deg184

Cited by 166 publications

(111 citation statements)

References 39 publications

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“…The study presented here used exclusively day 5 embryos and clearly demonstrates that acceptable pregnancy rates can be achieved using single embryo transfers in a relatively unselected population of IVF patients. This study confirms those conducted previously (Martikainen et al, 2001;Salumets et al, 2003;Tiitinen et al, 2001;Vilska et al, 1999) using day 3 embryos. Only one study ) has included cumulative pregnancy rate but unfortunately the data did not include the cumulative rate for those patients having two embryos transferred in their stimulated cycle.…”

Section: Discussionsupporting

confidence: 92%

Single Embryo Transfer in IVF to Prevent Multiple Pregnancies

Catt¹,

Wood

Henman

et al. 2003

Twin res.

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Section: Discussionsupporting

confidence: 92%

Single Embryo Transfer in IVF to Prevent Multiple Pregnancies

Catt¹,

Wood

Henman

et al. 2003

Twin res.

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“…Pregnancy rate by transfer of Day 2 embryos in the early cleaving group was significantly higher than that in the late cleaving group (Chi-squared test, P<0.05). The actual percentages are shown within the bars [11,12,17,18]. This study confirmed that embryos that had cleaved by 27 h had significantly higher blastocyst rates than later cleaving embryos.…”

Section: Discussionsupporting

confidence: 67%

Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection

Tomari

Honjou²,

Nagata³

et al. 2011

J Assist Reprod Genet

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Purpose To investigate the relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection (ICSI). Methods Zygotes that had cleaved to two-cell stage by 27 h post-ICSI were classified as early cleaving and the remainder as late cleaving. Meiotic spindle parameters previously imaged using the PolScope were compared between the two groups. Results Of 384 embryos, 163 were classed as early cleaving and 221 as late cleaving. The rate of blastocyst formation or pregnancy by Day 2 embryo transfer was significantly higher following early cleavage than after late cleavage (52.4% vs. 24.4% or 32.6% vs. 11.4%). Spindle areas (108.0 vs. 89.8 μm 2 ), lengths (14.7 vs. 13.4 μm) and PolScope retardance were also significantly greater in the early cleaving group. Conclusions Meiotic spindle parameters determine the timing of the first zygotic cleavage and are strong indicators of human embryo developmental potential.

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“…Both animal and human studies have demonstrated that timely entry into the first cleavage (so called Bearly cleavage^) is associated with developmentally more competent embryos compared with late cleavage or no cleavage [37]. Indeed, embryos that cleave between 24 and 27 h after fertilization are more developmentally competent, resulting in higher blastocyst and implantation rates compared with those that cleave relatively later [7,13,[38][39][40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

Machtinger

Bormann

Ginsburg

et al. 2015

J Assist Reprod Genet

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Purpose Morphological evaluation is currently considered the single most important predictive measure for assessing embryo quality. The aim of this study was to investigate whether cycles with at least one non-cleaved embryo (i.e., a 1-cell embryo on day 3) have different outcomes compared with cycles in which all embryos had cleaved by day 3. Methods All autologous IVF/ICSI cycles with a fresh day 3 transfer and without using a gestational carrier performed at our center between 1/1/2010 and 12/31/2011 were analyzed retrospectively. Those cycles with at least one non-cleaved embryo on day 3 were compared with all other autologous cycles that had l00 % cleaved embryos performed during the study period. Results Eight hundred and forty two cycles were included. Of them, 144 cycles comprised the non-cleaved group, and 698 cycles comprised the cleaved group. Cycles in the non-cleaved group had more oocytes retrieved (15.4±7.1 vs. 12.5±7.1, p<0.001), more zygotes obtained (10.0±5.3 vs. 7.9±5.2, p= <0.001), but the embryos exhibited lower cleavage rates and higher rates of fragmentation and asymmetry compared with controls (p<0.001). However, spontaneous abortion rates, ectopic pregnancies rates as well as delivery rates were similar between the two groups.Conclusions Our results show that the presence of a noncleaved embryo on day 3 is associated with a more exuberant response to controlled ovarian stimulation as reflected by more oocytes retrieved. Despite the significant decrease in quality of the whole cohort in the non-cleaved group, implantation, delivery rates and number of embryos frozen were not adversely affected by the presence of a non-cleaved embryo.

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Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures

Abstract: The current study provides compelling evidence that EC embryos possess significantly higher developmental competence than NEC embryos.

Cited by 166 publications

References 39 publications

Single Embryo Transfer in IVF to Prevent Multiple Pregnancies

Single Embryo Transfer in IVF to Prevent Multiple Pregnancies

Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

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